Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/13433
Title: Improving Long-Term Outcomes with Cardiac Resynchronization Therapy: Importance of Adjunctive Heart Failure Optimization Immediately After Implantation.
Authors: MULLENS, Wilfried 
Kepa, Jacek
DE VUSSER, Philip 
Vercammen, Jan
Rivero-Ayerza, Maximo
WAGNER, Patrick 
DENS, Jo 
VROLIX, Mathias 
VANDERVOORT, Pieter 
Tang, W.H. Wilson
Issue Date: 2011
Source: AMERICAN JOURNAL OF CARDIOLOGY, 108 (3), p. 409-415
Abstract: Despite improvement in morbidity and mortality with cardiac resynchronization therapy (CRT), disease progression continues to affect a subset of patients and there is limited effort to identify contributing factors. Our objective was to investigate if a protocol-driven approach incorporated in a management strategy of heart failure immediately after implantation would provide incremental benefits beyond usual care after implantation. We reviewed 114 consecutive patients with CRT implanted from 2005 through 2009 who received usual care after implantation or underwent protocol-driven CRT care after implantation. Preimplantation characteristics in patients receiving usual versus protocoldriven care were similar in left ventricular (LV) dimension (LV internal diastolic diameter 6.2 0.8 vs 6.4 1.0 cm), LV ejection fraction (26 8% vs 25% 8%), QRS width, and medication usage. Major adjustments during the protocol-driven approach were uptitration of neurohormonal blockers (64%), echocardiographically guided atrioventricular optimization (50%), heart failure education (42%), arrhythmia management (19%), and LV lead repositioning (7%). Although positive LV remodeling was noted in the 2 groups at 6 months, extent was significantly greater in the protocol-driven approach compared to usual care (change in LV internal diastolic diameter 0.7 0.6 cm vs 0.2 1.2 cm, p 0.01; change in LV ejection fraction 11 7% vs 7 9%, p 0.01), which was associated with fewer major adverse events (14% vs 53%, p <0.001). In conclusion, a protocol-driven approach for patients with CRT started immediately after implantation is associated with incremental favorable effects on reverse remodeling and fewer adverse events compared to usual care after implantation. These effects appeared to be driven not only by changes in device settings and arrhythmia management but also by concomitant medication optimization and heart failure education.
Document URI: http://hdl.handle.net/1942/13433
ISSN: 0002-9149
e-ISSN: 1879-1913
DOI: 10.1016/j.amjcard.2011.03.060
ISI #: 000293767400013
Category: A1
Type: Journal Contribution
Validations: ecoom 2013
Appears in Collections:Research publications

Files in This Item:
File Description SizeFormat 
importance of adjunctive heart failure.pdf
  Restricted Access
1.04 MBAdobe PDFView/Open    Request a copy
Show full item record

SCOPUSTM   
Citations

36
checked on Sep 3, 2020

WEB OF SCIENCETM
Citations

42
checked on Nov 26, 2022

Page view(s)

28
checked on Jul 20, 2022

Download(s)

10
checked on Jul 20, 2022

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.