Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/13565
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dc.contributor.authorRUMMENS, Jean-Luc-
dc.contributor.authorDaniels, A.-
dc.contributor.authorDENDALE, Paul-
dc.contributor.authorHENSEN, Karen-
dc.contributor.authorHENDRIKX, Marc-
dc.contributor.authorKONINCKX, Remco-
dc.contributor.authorHANSEN, Dominique-
dc.date.accessioned2012-04-13T13:54:34Z-
dc.date.available2012-04-13T13:54:34Z-
dc.date.issued2012-
dc.identifier.citationACTA CLINICA BELGICA, 67(4), p. 262-269.-
dc.identifier.issn0001-5512-
dc.identifier.urihttp://hdl.handle.net/1942/13565-
dc.description.abstractEndothelial progenitor cells (EPCs) significantly affect endothelial repair capacity and, hence, cardiovascular disease incidence. In healthy subjects, blood EPC content increases significantly as result of a single maximal exercise test, hereby stimulating endothelial repair capacity. It remains to be shown whether a single exercise positively affects blood EPCs in revascularised coronary artery disease (CAD) patients. From male revascularised CAD patients (n = 60) and healthy volunteers (n = 25) blood samples were collected before and immediately after a maximal cardiopulmonary exercise test. Blood samples were analyzed by optimised flow cytometry methodology for EPC content (CD34+, CD34+ CD133+, CD34+VEGFR2+, CD34+CD133+VEGFR2+, and CD34+CD133-VEGFR2+ cells) and compared between groups. CFU-Hill colonies were additionally assessed. As a result of a maximal exercise test, blood CD34+, CD34+VEGFR2+ (all EPCs), CD34+CD133+, and CD34+ CD133-VEGFR2+ (mature EPCs) cells increased significantly in CAD patients (p < 0.05), but less than in healthy subjects (p < 0.05, and p = 0.06 for CD34+VEGFR2+). CD34+CD133+VEGFR2+ cells (immature EPCs) did not change as result of exercise (p > 0.05). No changes in CFUHill colonies as result of exercise were observed. This study shows that blood mature EPCs (CD34+CD133- VEGFR2+) increase significantly as result of a single exercise bout in revascularised CAD patients, but with smaller magnitude compared to healthy subjects. Blood immature EPCs (CD34+CD133+VEGFR2+) did not change significantly as result of exercise.-
dc.language.isoen-
dc.titleSuppressed increase in blood endothelial progenitor cell content as result of single exhaustive exercise bout in male revascularised coronary artery disease patients.-
dc.typeJournal Contribution-
dc.identifier.epage269-
dc.identifier.issue4-
dc.identifier.spage262-
dc.identifier.volume67-
local.bibliographicCitation.jcatA1-
local.type.refereedRefereed-
local.type.specifiedArticle-
dc.bibliographicCitation.oldjcatA1-
dc.identifier.doi10.2143/ACB.67.0.2062000-
dc.identifier.isi000312513500007-
item.validationecoom 2014-
item.fulltextWith Fulltext-
item.accessRightsRestricted Access-
item.fullcitationRUMMENS, Jean-Luc; Daniels, A.; DENDALE, Paul; HENSEN, Karen; HENDRIKX, Marc; KONINCKX, Remco & HANSEN, Dominique (2012) Suppressed increase in blood endothelial progenitor cell content as result of single exhaustive exercise bout in male revascularised coronary artery disease patients.. In: ACTA CLINICA BELGICA, 67(4), p. 262-269..-
item.contributorDaniels, A.-
item.contributorHANSEN, Dominique-
item.contributorRUMMENS, Jean-Luc-
item.contributorKONINCKX, Remco-
item.contributorHENDRIKX, Marc-
item.contributorHENSEN, Karen-
item.contributorDENDALE, Paul-
crisitem.journal.issn0001-5512-
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