Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/13595
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | BROUX, Bieke | - |
dc.contributor.author | PANNEMANS, Kim | - |
dc.contributor.author | Zhang, Xin | - |
dc.contributor.author | Markovic-Plese, Silva | - |
dc.contributor.author | BROEKMANS, Tom | - |
dc.contributor.author | OP 'T EIJNDE, Bert | - |
dc.contributor.author | VAN WIJMEERSCH, Bart | - |
dc.contributor.author | SOMERS, Veerle | - |
dc.contributor.author | GEUSENS, Piet | - |
dc.contributor.author | van der Pol, Susanne | - |
dc.contributor.author | VAN HORSSEN, Jack | - |
dc.contributor.author | STINISSEN, Piet | - |
dc.contributor.author | HELLINGS, Niels | - |
dc.date.accessioned | 2012-04-27T11:48:45Z | - |
dc.date.available | 2012-04-27T11:48:45Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | JOURNAL OF AUTOIMMUNITY, 38 (1), p. 10-19 | - |
dc.identifier.issn | 0896-8411 | - |
dc.identifier.uri | http://hdl.handle.net/1942/13595 | - |
dc.description.abstract | Immunosenescence, or ageing of the immune system, contributes to the increased morbidity and mortality seen in the elderly population. Premature immunosenescence is shown to occur in a subgroup of patients with autoimmune diseases. One of the main characteristics of immunosenescence is the expansion of CD4(+)CD28(-) T cells in the blood. In this study, we investigate the potential contribution of these cells to disease processes in a subgroup of multiple sclerosis (MS) and rheumatoid arthritis (RA) patients. Characterization of CD4(+)CD28(-) T cells in patients and healthy controls reveals that they have an inflammation-seeking effector-memory T cell phenotype with cytotoxic properties, as they expel cytotoxic granules in response to a polyclonal stimulus or MS-related autoantigens. We identify CX(3)CR1, the fractalkine receptor, as a selective marker to discriminate CD4(+)CD28(-) T cells from their CD4(+)CD28(+) counterparts. CX(3)CR1 expression enables CD4(+)CD28(-) T cells to migrate towards a fractalkine gradient in vitro. In addition, we find increased levels of fractalkine in the cerebrospinal fluid and inflammatory lesions of MS patients. We demonstrate for the first time that CD4(+)CD28(-) T cells accumulate in MS lesions of a subgroup of patients. Moreover, we have indications that these cells are cytotoxic in the target tissue. Overall, our findings suggest that CD4(+)CD28(-) T cells migrate in response to a chemotactic gradient of fractalkine to sites of inflammation, where they contribute to the inflammatory processes in a subgroup of patients with MS and RA. (C) 2011 Elsevier Ltd. All rights reserved. | - |
dc.description.sponsorship | This work was supported by Hasselt University. We thank patients and healthy controls for blood donations, and Anne Bogaers for assistance in collecting the blood samples. We kindly thank Prof. Martin Schwab for providing us with the NogoA antibody. We also thank Anke Vanderstraeten, Kris Marcoen, Tijs Louwies, Marijke Brulmans and Kristof Notelaers for technical assistance. The authors have no conflicting financial interests. | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | - |
dc.rights | 2011 Elsevier Ltd. All rights reserved. | - |
dc.subject.other | Multiple sclerosis | - |
dc.subject.other | T cells | - |
dc.subject.other | Immunosenescence | - |
dc.subject.other | Fractalkine | - |
dc.subject.other | CX(3)CR1 | - |
dc.title | CX(3)CR1 drives cytotoxic CD4(+)CD28(-) T cells into the brain of multiple sclerosis patients | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 19 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 10 | - |
dc.identifier.volume | 38 | - |
local.format.pages | 10 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | [Broux, Bieke; Pannemans, Kim; Broekmans, Tom; Eijnde, Bert O.; Van Wijmeersch, Bart; Somers, Veerle; Geusens, Piet; Stinissen, Piet; Hellings, Niels] Hasselt Univ, Biomed Res Inst, B-3590 Diepenbeek, Belgium. [Broux, Bieke; Pannemans, Kim; Broekmans, Tom; Eijnde, Bert O.; Van Wijmeersch, Bart; Somers, Veerle; Geusens, Piet; Stinissen, Piet; Hellings, Niels] Transnat Univ Limburg, Sch Life Sci, B-3590 Diepenbeek, Belgium. [Zhang, Xin; Markovic-Plese, Silva] Univ N Carolina, Dept Neurol, Chapel Hill, NC 27514 USA. [Markovic-Plese, Silva] Univ N Carolina, Dept Microbiol & Immunol, Chapel Hill, NC 27514 USA. [Broekmans, Tom; Eijnde, Bert O.; Van Wijmeersch, Bart] PHL Univ Coll, REVAL Rehabil Res Ctr, Dpt Healthcare, B-3590 Diepenbeek, Belgium. [Van Wijmeersch, Bart] Mariaziekenhuis Noord Limburg, B-3900 Overpelt, Belgium. [Van Wijmeersch, Bart] Revalidatie & MS Ctr, B-3900 Overpelt, Belgium. [Geusens, Piet] Maastricht Univ Med Ctr, Dept Internal Med Rheumatol, NL-6229 HX Maastricht, Netherlands. [van der Pol, Susanne; van Horssen, Jack] Vrije Univ Amsterdam Med Ctr, Dept Mol Cell Biol & Immunol, NL-1081 BT Amsterdam, Netherlands. [van Horssen, Jack] Vrije Univ Amsterdam Med Ctr, Dept Neuropathol, NL-1081 BT Amsterdam, Netherlands. | - |
local.publisher.place | LONDON | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.bibliographicCitation.oldjcat | A1 | - |
dc.identifier.doi | 10.1016/j.jaut.2011.11.006 | - |
dc.identifier.isi | 000301313400002 | - |
local.uhasselt.international | yes | - |
item.accessRights | Restricted Access | - |
item.fullcitation | BROUX, Bieke; PANNEMANS, Kim; Zhang, Xin; Markovic-Plese, Silva; BROEKMANS, Tom; OP 'T EIJNDE, Bert; VAN WIJMEERSCH, Bart; SOMERS, Veerle; GEUSENS, Piet; van der Pol, Susanne; VAN HORSSEN, Jack; STINISSEN, Piet & HELLINGS, Niels (2012) CX(3)CR1 drives cytotoxic CD4(+)CD28(-) T cells into the brain of multiple sclerosis patients. In: JOURNAL OF AUTOIMMUNITY, 38 (1), p. 10-19. | - |
item.contributor | BROUX, Bieke | - |
item.contributor | PANNEMANS, Kim | - |
item.contributor | Zhang, Xin | - |
item.contributor | Markovic-Plese, Silva | - |
item.contributor | BROEKMANS, Tom | - |
item.contributor | OP 'T EIJNDE, Bert | - |
item.contributor | VAN WIJMEERSCH, Bart | - |
item.contributor | SOMERS, Veerle | - |
item.contributor | GEUSENS, Piet | - |
item.contributor | van der Pol, Susanne | - |
item.contributor | VAN HORSSEN, Jack | - |
item.contributor | STINISSEN, Piet | - |
item.contributor | HELLINGS, Niels | - |
item.fulltext | With Fulltext | - |
item.validation | ecoom 2013 | - |
crisitem.journal.issn | 0896-8411 | - |
crisitem.journal.eissn | 1095-9157 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
broux.pdf Restricted Access | Published version | 1.37 MB | Adobe PDF | View/Open Request a copy |
SCOPUSTM
Citations
64
checked on Sep 7, 2020
WEB OF SCIENCETM
Citations
92
checked on Apr 22, 2024
Page view(s)
66
checked on Aug 23, 2022
Download(s)
46
checked on Aug 23, 2022
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.