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http://hdl.handle.net/1942/13615
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DC Field | Value | Language |
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dc.contributor.author | JOZEFCZAK, Marijke | - |
dc.contributor.author | REMANS, Tony | - |
dc.contributor.author | VANGRONSVELD, Jaco | - |
dc.contributor.author | CUYPERS, Ann | - |
dc.date.accessioned | 2012-04-27T14:35:49Z | - |
dc.date.available | 2012-04-27T14:35:49Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 132 (3), p. 3145-3175 | - |
dc.identifier.issn | 1422-0067 | - |
dc.identifier.uri | http://hdl.handle.net/1942/13615 | - |
dc.description.abstract | Since the industrial revolution, the production, and consequently the emission of metals, has increased exponentially, overwhelming the natural cycles of metals in many ecosystems. Metals display a diverse array of physico-chemical properties such as essential versus non-essential and redox-active versus non-redox-active. In general, all metals can lead to toxicity and oxidative stress when taken up in excessive amounts, imposing a serious threat to the environment and human health. In order to cope with different kinds of metals, plants possess defense strategies in which glutathione (GSH; gamma-glu-cys-gly) plays a central role as chelating agent, antioxidant and signaling component. Therefore, this review highlights the role of GSH in: (1) metal homeostasis; (2) antioxidative defense; and (3) signal transduction under metal stress. The diverse functions of GSH originate from the sulfhydryl group in cysteine, enabling GSH to chelate metals and participate in redox cycling. | - |
dc.description.sponsorship | The authors apologize to any researcher whose work is not cited here due to limitations of space and scope. This work was supported by the Agency for Innovation by Science and Technology with a PhD grant for Marijke Jozefczak. Additional financial support was obtained from the Research Foundation-Flanders (FWO) project G.0807.09 and from the Methusalem project 08G03VGRJ. | - |
dc.language.iso | en | - |
dc.publisher | MDPI AG | - |
dc.subject.other | Multidisciplinary Chemistry; metals; cellular redox state; glutathione; chelation | - |
dc.subject.other | metals; cellular redox state; glutathione; chelation | - |
dc.title | Glutathione Is a Key Player in Metal-Induced Oxidative Stress Defenses | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 3175 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 3145 | - |
dc.identifier.volume | 132 | - |
local.format.pages | 31 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Cuypers, A (reprint author),Hasselt Univ, Ctr Environm Sci, Agoralaan Bldg D, B-3590 Diepenbeek, Belgium. [Jozefczak, Marijke; Remans, Tony; Vangronsveld, Jaco; Cuypers, Ann] marijke.jozefczak@uhasselt.be; tony.remans@uhasselt.be; jaco.vangronsveld@uhasselt.be; ann.cuypers@uhasselt.be | - |
local.publisher.place | BASEL | - |
local.type.refereed | Refereed | - |
local.type.specified | Review | - |
dc.bibliographicCitation.oldjcat | A1 | - |
dc.identifier.doi | 10.3390/ijms13033145 | - |
dc.identifier.isi | 000302174500038 | - |
item.validation | ecoom 2013 | - |
item.contributor | JOZEFCZAK, Marijke | - |
item.contributor | REMANS, Tony | - |
item.contributor | VANGRONSVELD, Jaco | - |
item.contributor | CUYPERS, Ann | - |
item.accessRights | Open Access | - |
item.fullcitation | JOZEFCZAK, Marijke; REMANS, Tony; VANGRONSVELD, Jaco & CUYPERS, Ann (2012) Glutathione Is a Key Player in Metal-Induced Oxidative Stress Defenses. In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 132 (3), p. 3145-3175. | - |
item.fulltext | With Fulltext | - |
crisitem.journal.issn | 1661-6596 | - |
crisitem.journal.eissn | 1422-0067 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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ijms-13-03145.pdf | Published version | 592.22 kB | Adobe PDF | View/Open |
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