Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/13628
Title: Immune response and immunotherapy in intraepithelial and invasive lesions of the uterine cervix
Authors: Machado, F. A.
JANSSENS, Jaak 
Michelin, M. A.
Murta, E. F. C.
Issue Date: 2012
Publisher: I R O G CANADA, INC
Source: CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY, 39 (1), p. 27-31
Abstract: Infection with the human papillomavirus virus (HPV) induces innate and acquired immune responses in the cervical stroma, which are a delicate, balanced and generally unpredictable immunological defense. Because of the immunological breaks that the HPV virus causes, eradication of infected cells does not occur, potentially leading to development of intraepithelial and invasive lesions. Advances in our understanding of the immune system and in the definition of antigens in tumor cells has led to many new treatment strategies. As a result, immunotherapy has the potential to be the most specific treatment for tumors, and one that requires elaboration. Recently, immunotherapy with interferon and dendrite cells has been used on intrapepithelial and invasive cervical lesions with promising results.
Notes: [Murta, E. F. C.] Univ Fed Triangulo Mineiro, Oncol Res Inst, Inst Pesquisa Oncol, IPON, BR-38025440 Uberaba, MG, Brazil. [Janssens, J. Ph.] Univ Hasselt, Dept Oncol, Diepenbeek, Belgium. [Michelin, M. A.; Murta, E. F. C.] Univ Fed Triangulo Mineiro, Oncol Res Inst IPON, Discipline Gynecol & Obstet, BR-38025440 Uberaba, MG, Brazil.
Keywords: Obstetrics & Gynecology; Cervical intraepithelial neoplasia; Human papillomavirus; Immunotherapy; Interferon and dendrite cells;Cervical intraepithelial neoplasia; Human papillomavirus; Immunotherapy; Interferon and dendrite cells
Document URI: http://hdl.handle.net/1942/13628
ISSN: 0390-6663
e-ISSN: 0390-6663
ISI #: 000301509900008
Category: A1
Type: Journal Contribution
Validations: ecoom 2013
Appears in Collections:Research publications

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