Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/13720
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dc.contributor.authorALENUS, Jan-
dc.contributor.authorGALAR, Pavel-
dc.contributor.authorETHIRAJAN, Anitha-
dc.contributor.authorHOREMANS, Frederik-
dc.contributor.authorWEUSTENRAED, Ans-
dc.contributor.authorCLEIJ, Thomas-
dc.contributor.authorWAGNER, Patrick-
dc.date.accessioned2012-06-06T08:09:22Z-
dc.date.available2012-06-06T08:09:22Z-
dc.date.issued2012-
dc.identifier.citationPHYSICA STATUS SOLIDI A-APPLICATIONS AND MATERIALS SCIENCE, 209 (5), p. 905-910-
dc.identifier.issn1862-6300-
dc.identifier.urihttp://hdl.handle.net/1942/13720-
dc.description.abstractSynthetic materials with imprinted nanocavities can act as highly selective tailor-made artificial receptors. Implementing these materials in a piezoelectric sensing device can offer fast and straightforward detection together with high sensitivity. L-nicotine, a major addictive substance in cigarettes is used as target molecule. The synthetic receptors for L-nicotine are made via the molecular imprinting technique. The target molecule is added to a monomer mixture containing initiator and this mixture is polymerized with heat. Subsequently, microparticles are obtained by crushing the bulk molecular imprinted polymers (MIPs), which are then immobilized on thin films of polyvinyl chloride. Using Quartz crystal microbalance, L-nicotine could be detected in the submicromolar range and the selectivity of the sensors was verified by reference measurements with L-cotinine. The effectiveness of the sensor was also tested for different aqueous fluids at different pH. It was found that MIPs bind 4.03 times more L-nicotine than non-imprinted polymer in water and 1.99 times more in 0.1 x phosphate buffer saline at pH 9. (c) 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim-
dc.description.sponsorshipThis work is supported by an IMEC Ph.D. Fellowship, Life-Science Initiative of the Province of Limburg (J. Alenus) and by Charles University (project SVV-2011-263306, 151910 and Mobility Fund) (P. Galar). For technical assistance the authors also would like to thank H. Penxten, J. Sogen, C. Willems and J. Baccus.-
dc.language.isoen-
dc.publisherWILEY-V C H VERLAG GMBH-
dc.subject.otheraqueous fluids; dissipation detection; L-nicotine; molecular imprinted polymer; quartz crystal microbalance-
dc.subject.otherMultidisciplinary Materials Science; Applied Physics; Condensed Matter Physics, aqueous fluids; dissipation detection; L-nicotine; molecular imprinted polymer; quartz crystal microbalance-
dc.titleDetection of L-nicotine with dissipation mode quartz crystal microbalance using molecular imprinted polymers-
dc.typeJournal Contribution-
dc.identifier.epage910-
dc.identifier.issue5-
dc.identifier.spage905-
dc.identifier.volume209-
local.format.pages6-
local.bibliographicCitation.jcatA1-
dc.description.notes[Alenus, Jan; Ethirajan, Anitha; Horemans, Frederik; Weustenraed, Ans; Cleij, Thomas J.; Wagner, Patrick] Hasselt Univ, Inst Mat Res IMO, B-3590 Diepenbeek, Belgium. [Galar, Pavel] Charles Univ Prague, Fac Math & Phys, CR-12116 Prague 2, Czech Republic. [Wagner, Patrick] IMEC Div IMOMEC, B-3590 Diepenbeek, Belgium. patrick.wagner@uhasselt.be-
local.publisher.placeWEINHEIM-
local.type.refereedRefereed-
local.type.specifiedArticle-
dc.bibliographicCitation.oldjcatA1-
dc.identifier.doi10.1002/pssa.201100768-
dc.identifier.isi000303386900018-
item.fullcitationALENUS, Jan; GALAR, Pavel; ETHIRAJAN, Anitha; HOREMANS, Frederik; WEUSTENRAED, Ans; CLEIJ, Thomas & WAGNER, Patrick (2012) Detection of L-nicotine with dissipation mode quartz crystal microbalance using molecular imprinted polymers. In: PHYSICA STATUS SOLIDI A-APPLICATIONS AND MATERIALS SCIENCE, 209 (5), p. 905-910.-
item.fulltextWith Fulltext-
item.accessRightsRestricted Access-
item.validationecoom 2013-
item.contributorCLEIJ, Thomas-
item.contributorALENUS, Jan-
item.contributorETHIRAJAN, Anitha-
item.contributorHOREMANS, Frederik-
item.contributorWEUSTENRAED, Ans-
item.contributorGALAR, Pavel-
item.contributorWAGNER, Patrick-
crisitem.journal.issn1862-6300-
crisitem.journal.eissn1862-6319-
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