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|Title:||Microfluidic chip with integrated microvalves based on temperature- and pH-responsive hydrogel thin films||Authors:||Baecker, M.
Schoening, M. J.
|Issue Date:||2012||Publisher:||WILEY-V C H VERLAG GMBH||Source:||PHYSICA STATUS SOLIDI A-APPLICATIONS AND MATERIALS SCIENCE, 209 (5), p. 839-845||Abstract:||Two types of microvalves based on temperature-responsive poly(N-isopropylacrylamide) (PNIPAAm) and pH-responsive poly(sodium acrylate) (PSA) hydrogel films have been developed and tested. The PNIPAAm and PSA hydrogel films were prepared by means of in situ photopolymerization directly inside the fluidic channel of a microfluidic chip fabricated by combining Si and SU-8 technologies. The swelling/shrinking properties and height changes of the PNIPAAm and PSA films inside the fluidic channel were studied at temperatures of deionized water from 14 to 36 degrees C and different pH values (pH 3-12) of Titrisol buffer, respectively. Additionally, in separate experiments, the lower critical solution temperature (LCST) of the PNIPAAm hydrogel was investigated by means of a differential scanning calorimetry (DSC) and a surface plasmon resonance (SPR) method. Mass-flow measurements have shown the feasibility of the prepared hydrogel films to work as an on-chip integrated temperature- or pH-responsive microvalve capable to switch the flow channel on/off. (c) 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim||Notes:||[Baecker, M.; Schusser, S.; Jeitner, C.; Breuer, L.; Poghossian, A.; Foerster, A.; Schoening, M. J.] Aachen Univ Appl Sci, Inst Nano & Biotechnol INB, D-52428 Julich, Germany. [Baecker, M.; Schusser, S.; Poghossian, A.; Schoening, M. J.] Res Ctr Julich, Peter Grunberg Inst PGI 8, D-52425 Julich, Germany. [Raue, M.; Mang, T.] Aachen Univ Appl Sci, Inst Appl Polymer Chem IAP, D-52428 Julich, Germany. [Wagner, P.] Hasselt Univ, Inst Mat Res, B-3590 Diepenbeek, Belgium. email@example.com||Keywords:||microfluidics; microvalve; photopolymerization; responsive hydrogels;Multidisciplinary Materials Science; Applied Physics; Condensed Matter Physics; microfluidics; microvalve; photopolymerization; responsive hydrogels||Document URI:||http://hdl.handle.net/1942/13721||ISSN:||1862-6300||e-ISSN:||1862-6319||DOI:||10.1002/pssa.201100763||ISI #:||000303386900007||Category:||A1||Type:||Journal Contribution||Validations:||ecoom 2013|
|Appears in Collections:||Research publications|
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