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Title: Estimating the force of infection for HCV in injecting drug users using interval-censored data
Authors: CASTRO SANCHEZ, Amparo 
HENS, Niel 
AERTS, Marc 
Geskus, R.
Prins, M.
Wiessing, L.
Kretzschmar, M.
Issue Date: 2012
Source: EPIDEMIOLOGY AND INFECTION, 140 (6), p. 1064-1074
Abstract: Injecting drug users (IDUs) account for most new HCV infections. The objectives of this study were: to estimate the force of infection for hepatitis C virus in IDUs within the interval-censoring framework and to determine the impact of risk factors such as frequency of injection, drug injected, sharing of syringes and time of first injection on the time to HCV infection. We used data from the Amsterdam Cohort Study collected in The Netherlands and focused on those individuals who were HCV negative upon entry into the study. Based on the results, the force of infection was found to vary with time of first injection. The risk of infection was higher in the first 3 years of an IDU's career, implying estimates based on single cross-sectional studies could be biased. Frequency of injection and type of drug injected were found to be highly significant predictors, whereas sharing syringes was not.
Notes: [Castro-Sanchez, A.; Shkedy, Z.; Hens, N.; Aerts, M.] Hasselt Univ, Interuniv Inst Biostat & Stat Bioinformat, Diepenbeek, Belgium. [Hens, N.] Univ Antwerp, Ctr Evaluat Vaccinat, Vaccine & Infect Dis Inst, Ctr Hlth Econ Res & Modelling Infect Dis, B-2020 Antwerp, Belgium. [Geskus, R.; Prins, M.] Publ Hlth Serv Amsterdam, Dept Res, Amsterdam, Netherlands. [Geskus, R.] Univ Amsterdam, Acad Med Ctr, Dept Clin Epidemiol Biostat & Bioinformat, NL-1105 AZ Amsterdam, Netherlands. [Prins, M.] Univ Amsterdam, Acad Med Ctr, Ctr Immun & Infect Amsterdam CINIMA, NL-1105 AZ Amsterdam, Netherlands. [Wiessing, L.] EMCDDA, Lisbon, Portugal. [Kretzschmar, M.] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands. [Kretzschmar, M.] RIVM, Ctr Infect Dis Control, Bilthoven, Netherlands.
Keywords: Epidemiology; hepatitis C;Public, Environmental & Occupational Health; Infectious Diseases
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ISSN: 0950-2688
e-ISSN: 1469-4409
DOI: 10.1017/S0950268811001750
ISI #: 000304007700013
Category: A1
Type: Journal Contribution
Validations: ecoom 2013
Appears in Collections:Research publications

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