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Title: Towards water compatible MIPs for sensing in aqueous media
Authors: HOREMANS, Frederik 
Spivak, D.
Cleij, T. J.
Issue Date: 2012
Source: JOURNAL OF MOLECULAR RECOGNITION, 25 (6), p. 344-351
Abstract: When synthesizing molecularly imprinted polymers (MIPs), a few fundamental principles should be kept in mind. There is a strong correlation between porogen polarity, MIP microenvironment polarity and the imprinting effect itself. The combination of these parameters eventually determines the overall binding behavior of a MIP in a given solvent. In addition, it is shown that MIP binding is strongly influenced by the polarity of the rebinding solvent. Because the use of MIPs in biomedical environments is of considerable interest, it is important that these MIPs perform well in aqueous media. In this article, various approaches are explored towards a water compatible MIP for the target molecule l-nicotine. To this end, the imprinting effect together with the MIP matrix polarity is fine-tuned during MIP synthesis. The binding behavior of the resulting MIPs is evaluated by performing batch rebinding experiments that makes it possible to select the most suitable MIP/non-imprinted polymer couple for future application in aqueous environments. One method to achieve improved compatibility with water is referred to as porogen tuning, in which porogens of varying polarities are used. It is demonstrated that, especially when multiple porogens are mixed, this approach can lead to superior performance in aqueous environments. Another method involves the incorporation of polar or non-polar comonomers in the MIP matrix. It is shown that by carefully selecting these monomers, it is also possible to obtain MIPs, which can selectively bind their target in water. Copyright (c) 2012 John Wiley & Sons, Ltd.
Notes: [Cleij, T. J.] Maastricht Univ, Maastricht Sci Programme, NL-6200 MD Maastricht, Netherlands. [Horemans, F.; Weustenraed, A.; Cleij, T. J.] Hasselt Univ, Inst Mat Res, B-3590 Diepenbeek, Belgium. [Spivak, D.] Louisiana State Univ, Dept Chem, Baton Rouge, LA 70803 USA.
Keywords: Biochemistry & Molecular Biology; Biophysics; molecular imprinting; water compatibility; I-nicotine; porogen tuning; biosensors;molecular imprinting; water compatibility; l-nicotine; porogen tuning; biosensors
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ISSN: 0952-3499
e-ISSN: 1099-1352
DOI: 10.1002/jmr.2191
ISI #: 000304468900007
Category: A1
Type: Journal Contribution
Validations: ecoom 2013
Appears in Collections:Research publications

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