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http://hdl.handle.net/1942/13952
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DC Field | Value | Language |
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dc.contributor.author | Singh, Neha | - |
dc.contributor.author | Van Craeyveld, Eline | - |
dc.contributor.author | Tjwa, Marc | - |
dc.contributor.author | Ciarka, Agnieszka | - |
dc.contributor.author | Emmerechts, Jan | - |
dc.contributor.author | Droogne, Walter | - |
dc.contributor.author | Gordts, Stephanie C. | - |
dc.contributor.author | Carlier, Vincent | - |
dc.contributor.author | Jacobs, Frank | - |
dc.contributor.author | FIEUWS, Steffen | - |
dc.contributor.author | Vanhaecke, Johan | - |
dc.contributor.author | Van Cleemput, Johan | - |
dc.contributor.author | De Geest, Bart | - |
dc.date.accessioned | 2012-09-05T12:41:05Z | - |
dc.date.available | 2012-09-05T12:41:05Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 60 (4), p. 324-331 | - |
dc.identifier.issn | 0735-1097 | - |
dc.identifier.uri | http://hdl.handle.net/1942/13952 | - |
dc.description.abstract | Objectives Maintenance of endothelial homeostasis may prevent the development of cardiac allograft vasculopathy (CAV). This study investigated whether biomarkers related to endothelial injury and endothelial repair discriminate between CAV-negative and CAV-positive heart transplant recipients. Background CAV is the most important determinant of cardiac allograft survival and a major cause of death after heart transplantation. Methods Fifty-two patients undergoing coronary angiography between 5 and 15 years after heart transplantation were recruited in this study. Flow cytometry was applied to quantify endothelial progenitor cells (EPCs), circulating endothelial cells (CECs), and endothelial microparticles. Cell culture was used for quantification of circulating EPC number and hematopoietic progenitor cell number and for analysis of EPC function. Results The EPC number and function did not differ between CAV-negative and CAV-positive patients. In univariable models, age, creatinine, steroid dose, granulocyte colony-forming units, apoptotic CECs, and apoptotic endothelial microparticles discriminated between CAV-positive and CAV-negative patients. The logistic regression model containing apoptotic CECs and apoptotic endothelial microparticles as independent predictors provided high discrimination between CAV-positive and CAV-negative patients (C-statistic 0.812; 95% confidence interval: 0.692 to 0.932). In a logistic regression model with age and creatinine as covariates, apoptotic CECs (p = 0.0112) and apoptotic endothelial microparticles (p = 0.0141) were independent predictors (C-statistic 0.855; 95% confidence interval: 0.756 to 0.953). These 2 biomarkers remained independent predictors when steroid dose was introduced in the model. Conclusions The high discriminative ability of apoptotic CECs and apoptotic endothelial microparticles is a solid foundation for the development of clinical prediction models of CAV. (J Am Coll Cardiol 2012;60:324-31) (C) 2012 by the American College of Cardiology Foundation | - |
dc.description.sponsorship | This work was supported by Grant G.0529.10N of the Fonds voor Wetenschappelijk Onderzoek-Vlaanderen. Dr. Van Craeyveld is a Research Assistant of the Fonds voor Wetenschappelijk Onderzoek-Vlaanderen. Ms. Gordts is a Research Assistant of the Agentschap voor Innovatie door Wetenschap en Technologie. Dr. Jacobs is a postdoctoral fellow of the Fonds voor Wetenschappelijk Onderzoek-Vlaanderen. All other authors have reported they have no relationships relevant to the contents of this paper to disclose. | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.subject.other | Cardiac & Cardiovascular Systems; apoptotic circulating microparticles; biomarkers; cardiac allograft vasculopathy; circulating apoptotic endothelial cells; clinical prediction model | - |
dc.subject.other | apoptotic circulating microparticles; biomarkers; cardiac allograft vasculopathy; circulating apoptotic endothelial cells; clinical prediction model | - |
dc.title | Circulating Apoptotic Endothelial Cells and Apoptotic Endothelial Microparticles Independently Predict the Presence of Cardiac Allograft Vasculopathy | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 331 | - |
dc.identifier.issue | 4 | - |
dc.identifier.spage | 324 | - |
dc.identifier.volume | 60 | - |
local.format.pages | 8 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | [Singh, Neha; Van Craeyveld, Eline; Tjwa, Marc; Emmerechts, Jan; Gordts, Stephanie C.; Carlier, Vincent; Jacobs, Frank; De Geest, Bart] Univ Leuven, Ctr Mol & Vasc Biol, B-3000 Louvain, Belgium. [Tjwa, Marc] Goethe Univ Frankfurt, Lab Vasc Hematol Angiogenesis, Inst Transfus Med, Frankfurt, Germany. [Ciarka, Agnieszka; Droogne, Walter; Vanhaecke, Johan; Van Cleemput, Johan] Univ Hosp Leuven, Div Cardiol, Louvain, Belgium. [Fieuws, Steffen] Univ Hasselt, Louvain, Belgium. [Fieuws, Steffen] Univ Leuven, Interuniv Inst Biostat & Stat Bioinformat, B-3000 Louvain, Belgium. bart.degeest@med.kuleuven.be | - |
local.publisher.place | NEW YORK | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.bibliographicCitation.oldjcat | A1 | - |
dc.identifier.doi | 10.1016/j.jacc.2012.02.065 | - |
dc.identifier.isi | 000306486300009 | - |
item.contributor | Singh, Neha | - |
item.contributor | Van Craeyveld, Eline | - |
item.contributor | Tjwa, Marc | - |
item.contributor | Ciarka, Agnieszka | - |
item.contributor | Emmerechts, Jan | - |
item.contributor | Droogne, Walter | - |
item.contributor | Gordts, Stephanie C. | - |
item.contributor | Carlier, Vincent | - |
item.contributor | Jacobs, Frank | - |
item.contributor | FIEUWS, Steffen | - |
item.contributor | Vanhaecke, Johan | - |
item.contributor | Van Cleemput, Johan | - |
item.contributor | De Geest, Bart | - |
item.validation | ecoom 2013 | - |
item.fulltext | With Fulltext | - |
item.fullcitation | Singh, Neha; Van Craeyveld, Eline; Tjwa, Marc; Ciarka, Agnieszka; Emmerechts, Jan; Droogne, Walter; Gordts, Stephanie C.; Carlier, Vincent; Jacobs, Frank; FIEUWS, Steffen; Vanhaecke, Johan; Van Cleemput, Johan & De Geest, Bart (2012) Circulating Apoptotic Endothelial Cells and Apoptotic Endothelial Microparticles Independently Predict the Presence of Cardiac Allograft Vasculopathy. In: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 60 (4), p. 324-331. | - |
item.accessRights | Restricted Access | - |
crisitem.journal.issn | 0735-1097 | - |
crisitem.journal.eissn | 1558-3597 | - |
Appears in Collections: | Research publications |
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singh 1.pdf Restricted Access | Published version | 425.37 kB | Adobe PDF | View/Open Request a copy |
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