Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/13956
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dc.contributor.authorHENS, Niel-
dc.contributor.authorCalatayud, Laurence-
dc.contributor.authorKurkela, Satu-
dc.contributor.authorTamme, Teele-
dc.contributor.authorWallinga, Jacco-
dc.date.accessioned2012-09-05T13:25:05Z-
dc.date.available2012-09-05T13:25:05Z-
dc.date.issued2012-
dc.identifier.citationAMERICAN JOURNAL OF EPIDEMIOLOGY, 176 (3), p. 196-203-
dc.identifier.issn0002-9262-
dc.identifier.urihttp://hdl.handle.net/1942/13956-
dc.description.abstractThe rapid spread of the new influenza virus A(H1N1)v in young age groups in 2009 has been partly attributed to a high transmission intensity in schools. However, detailed characterization of the spread of influenza in school populations has been difficult to obtain, simply because it is very hard to identify who infected whom in a large outbreak. Data collected in large outbreak investigations typically miss many transmission events, and some reported transmission events will be incorrect. Here the authors present robust likelihood-based methods that can be used to analyze outbreak data while explicitly accounting for both missing data and erroneous data. They apply this method to a school-based outbreak of pandemic influenza A(H1N1)v that occurred in London, United Kingdom, in April 2009. The authors show that the generation interval in this school-based population was 2.20 days and that the reproduction number declined coincident with school closure, from 1.33 secondary cases per primary case to 0.43 secondary cases per primary case. These results provide quantitative evidence for the change in influenza transmission that is to be expected from school closure.-
dc.description.sponsorshipN. H. was supported by SIMID (Simulation Models of Infectious Disease Transmission and Control Processes), a strategic basic research project funded by the Institute for the Promotion of Innovation by Science and Technology in Flanders, Belgium (project 060081), and by the Belgian government's IAP (Interuniversity Attraction Poles) research network (Belgian Science Policy Office) (grant P6/03). N. H. also received support from the University of Antwerp Scientific Chair in Evidence Based Vaccinology. J. W. received research funding from the European Union FP7 FluModCont Project (grant 20160). S. K. was supported by the European Public Health Microbiology Training Programme, which was developed and endorsed by the establishment of a collaborative network of European laboratories for outbreak assistance and support, coordinated by the European Network for Diagnostics of "Imported" Viral Diseases and the European Centre for Disease Prevention and Control.-
dc.language.isoen-
dc.publisherOXFORD UNIV PRESS INC-
dc.subject.otherPublic, Environmental & Occupational Health; basic reproduction number; communicable diseases; disease outbreaks; disease transmission; infectious; epidemiologic measures; influenza A virus; H1N1 subtype; missing data-
dc.subject.otherbasic reproduction number; communicable diseases; disease outbreaks; disease transmission; infectious; epidemiologic methods; influenza A virus; H1N1 subtype; missing data-
dc.titleRobust Reconstruction and Analysis of Outbreak Data: Influenza A(H1N1)v Transmission in a School-based Population-
dc.typeJournal Contribution-
dc.identifier.epage203-
dc.identifier.issue3-
dc.identifier.spage196-
dc.identifier.volume176-
local.format.pages8-
local.bibliographicCitation.jcatA1-
dc.description.notes[Hens, Niel] Hasselt Univ, Interuniv Inst Biostat & Stat Bioinformat, B-3590 Diepenbeek, Belgium. niel.hens@uhasselt.be-
local.publisher.placeCARY-
local.type.refereedRefereed-
local.type.specifiedArticle-
dc.bibliographicCitation.oldjcatA1-
dc.identifier.doi10.1093/aje/kws006-
dc.identifier.isi000306923800004-
item.accessRightsRestricted Access-
item.fulltextWith Fulltext-
item.validationecoom 2013-
item.contributorHENS, Niel-
item.contributorCalatayud, Laurence-
item.contributorKurkela, Satu-
item.contributorTamme, Teele-
item.contributorWallinga, Jacco-
item.fullcitationHENS, Niel; Calatayud, Laurence; Kurkela, Satu; Tamme, Teele & Wallinga, Jacco (2012) Robust Reconstruction and Analysis of Outbreak Data: Influenza A(H1N1)v Transmission in a School-based Population. In: AMERICAN JOURNAL OF EPIDEMIOLOGY, 176 (3), p. 196-203.-
crisitem.journal.issn0002-9262-
crisitem.journal.eissn1476-6256-
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