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http://hdl.handle.net/1942/14212
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DC Field | Value | Language |
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dc.contributor.advisor | WAGNER, Patrick | - |
dc.contributor.advisor | INGEBRANDT, Sven | - |
dc.contributor.author | Lanche, Ruben | - |
dc.date.accessioned | 2012-09-27T10:28:44Z | - |
dc.date.available | 2012-09-27T10:28:44Z | - |
dc.date.issued | 2012 | - |
dc.identifier.uri | http://hdl.handle.net/1942/14212 | - |
dc.description.abstract | An array of four Au-IDEs was fabricated on Si/SiO2 and glass substrates. The active area of the fabricated IDEs has been functionalized with a GO layer using dielectrophoresis (DEP). The GO layer was reduced using L-Ascorbic Acid (L-AA). Finally, the surface of each rGO-IDE was functionalized with single-stranded DNA (ssDNA) molecules with perfectly matched or fully mismatched DNA-sequences to that of the complementary ssDNA (cDNA) molecules. For detection of the DNA hybridization and denaturation, the developed DNA-chip was mounted in a measurement cell and characterized by impedance spectroscopy (IS). The DNA hybridization and denaturation experiments were carried out in a differential IS setup using an impedance analyzer to eliminate the effect of disturbing factors in the sensor's signal. Changes in impedance for the sensors functionalized with perfect-matched ssDNA after a hybridization event were observed in contrast to almost no change when fully miss-matched ssDNA was used. | - |
dc.format.mimetype | Application/pdf | - |
dc.language | nl | - |
dc.language.iso | en | - |
dc.publisher | tUL Diepenbeek | - |
dc.title | Detection of DNA-Hybridization Using Interdigitated Electrodes Functionalized with Graphene | - |
dc.type | Theses and Dissertations | - |
local.bibliographicCitation.jcat | T2 | - |
dc.description.notes | master in de biomedische wetenschappen-bio-elektronica en nanotechnologie | - |
local.type.specified | Master thesis | - |
dc.bibliographicCitation.oldjcat | D2 | - |
item.fullcitation | Lanche, Ruben (2012) Detection of DNA-Hybridization Using Interdigitated Electrodes Functionalized with Graphene. | - |
item.fulltext | With Fulltext | - |
item.contributor | Lanche, Ruben | - |
item.accessRights | Open Access | - |
Appears in Collections: | Master theses |
Files in This Item:
File | Description | Size | Format | |
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10302762011254.pdf | 2.73 MB | Adobe PDF | View/Open |
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