Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/14218
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dc.contributor.authorNYSEN, Ruth-
dc.contributor.authorAERTS, Marc-
dc.contributor.authorFAES, Christel-
dc.date.accessioned2012-09-28T11:09:43Z-
dc.date.available2012-09-28T11:09:43Z-
dc.date.issued2012-
dc.identifier.citationSTATISTICS IN MEDICINE, 31 (21), p. 2374-2385-
dc.identifier.issn0277-6715-
dc.identifier.urihttp://hdl.handle.net/1942/14218-
dc.description.abstractWe propose and study a goodness-of-fit test for left-censored, right-censored, and interval-censored data assuming random censorship. Main motivation comes from dietary exposure assessment in chemical risk assessment, where the determination of an appropriate distribution for concentration data is of major importance. We base the new goodness-of-fit test procedure proposed in this paper on the order selection test. As part of the testing procedure, we extend the null model to a series of nested alternative models for censored data. Then, we use a modified AIC model selection to select the best model to describe the data. If a model with one or more extra parameters is selected, then we reject the null hypothesis. As an alternative to the use of the asymptotic null distribution of the test statistic, we define a bootstrap-based procedure. We illustrate the applicability of the test procedure on data of cadmium concentrations and on data from the Signal Tandmobiel study and demonstrate its performance characteristics through simulation studies. Copyright (c) 2012 John Wiley & Sons, Ltd.-
dc.description.sponsorshipThis research was supported by the IAP research network nr P6/03 of the Belgian Government (Belgian Science Policy). The computational resources and services used in this work were provided by the VSC (Flemish Supercomputer Center), funded by the Research Foundation - Flanders (FWO) and the Flemish Government – department EWI. The authors thank the members of the EFSA Working Group on Left Censored Data (Martine Bakker, Peter Furst, Gerhard Heinemeyer, Jessica Tressou, Philippe Verger, and the EFSA staff members Pietro Ferrari, Olaf Mosbach-Schulz, and Billy Amzal) and are grateful to EFSA for the approval to use the cadmium data (EFSA/DATEX/2007/005). The authors also thank Professor Emmanuel Lesaffre for the data and information on the Signal Tandmobiel project.-
dc.language.isoen-
dc.publisherWILEY-BLACKWELL-
dc.subject.otherMathematical & Computational Biology; Public, Environmental & Occupational Health; Medical Informatics; Medicine, Research & Experimental; Statistics & Probability; bootstrap test; censored data; goodness-of-fit test; order selection test; semi-nonparametric estimator-
dc.subject.otherbootstrap test; censored data; goodness-of-fit test; order selection test; semi-nonparametric estimator-
dc.titleTesting goodness of fit of parametric models for censored data-
dc.typeJournal Contribution-
dc.identifier.epage2385-
dc.identifier.issue21-
dc.identifier.spage2374-
dc.identifier.volume31-
local.format.pages12-
local.bibliographicCitation.jcatA1-
dc.description.notes[Nysen, Ruth; Aerts, Marc; Faes, Christel] Univ Hasselt, Interuniv Inst Biostat & Stat Bioinformat I BioSt, Ctr Stat, B-3590 Diepenbeek, Belgium. ruth.nysen@uhasselt.be-
local.publisher.placeHOBOKEN-
local.type.refereedRefereed-
local.type.specifiedArticle-
dc.bibliographicCitation.oldjcatA1-
local.type.programmeVSC-
dc.identifier.doi10.1002/sim.5368-
dc.identifier.isi000308209000007-
item.fulltextWith Fulltext-
item.contributorNYSEN, Ruth-
item.contributorAERTS, Marc-
item.contributorFAES, Christel-
item.accessRightsRestricted Access-
item.fullcitationNYSEN, Ruth; AERTS, Marc & FAES, Christel (2012) Testing goodness of fit of parametric models for censored data. In: STATISTICS IN MEDICINE, 31 (21), p. 2374-2385.-
item.validationecoom 2013-
crisitem.journal.issn0277-6715-
crisitem.journal.eissn1097-0258-
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