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http://hdl.handle.net/1942/14236
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DC Field | Value | Language |
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dc.contributor.author | MARTENS, Wendy | - |
dc.contributor.author | BRONCKAERS, Annelies | - |
dc.contributor.author | HILKENS, Petra | - |
dc.contributor.author | GERVOIS, Pascal | - |
dc.contributor.author | POLITIS, Constantinus | - |
dc.contributor.author | LAMBRICHTS, Ivo | - |
dc.date.accessioned | 2012-10-05T08:33:58Z | - |
dc.date.available | 2012-10-05T08:33:58Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 6 (Special Issue, Supplement 1), p. 80-80 | - |
dc.identifier.issn | 1932-6254 | - |
dc.identifier.uri | http://hdl.handle.net/1942/14236 | - |
dc.description.abstract | Stem cell-based therapies can be a future novel strategy to repair peripheral nerve injury, based on their multilineage differentiation potential and ability to produce and secrete neuro(trophic) factors. Recently, a possible transdifferentiation of MSC into SC have been demonstrated which had a positive effect on neuronal survival and neurite outgrowth. In this study, dental pulp stem cells (DPSC) are differentiated toward SC via a mix of growth factors. In addition the influence of secreted neurotrophic factors bt DPSC and SC-DPSC on neuronal outgrowth and survival is investigated. After 21 days of differentiation, the expression of SC-markers, GFAP, p75 and S100 was observed together with a decreased expression of nestin and Stro-1. Ultrastructurally, SC-DPSC displayed a spindle-shaped bipolar morphology with numerous organelles spread throughout the cell cytoplasm. Furthermore, collagen fibers were observed in the extracellular matrix. DPSC and SC-DPSC produced and secreted several neurotrophic factors which promoted the survival and neurite outgrowth in DRG cultures, with SC-DPSC yielding a significantly better effect than control DPSC. The results of this study indicate that DPSC are capable of differentiating towards SC. Moreover, differentiated DPSC had a better neuroprotective and neurotrophic effect than naïve stem cells suggesting that DPSC can be good candidates for cell-based therapies as treatment for peripheral nerve injuries. | - |
dc.language.iso | en | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.subject.other | Cell & Tissue Engineering; Biotechnology & Applied Microbiology; Cell Biology; Engineering, Biomedical | - |
dc.title | Human dental pulp stem cells have a positive influence on neural regeneration | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 80 | - |
dc.identifier.issue | Special Issue, Supplement 1 | - |
dc.identifier.spage | 80 | - |
dc.identifier.volume | 6 | - |
local.format.pages | 1 | - |
local.bibliographicCitation.jcat | M | - |
dc.description.notes | [Martens, M. W.; Bronckaers, B. A.; Hilkens, H. P.; Gervois, G. P.; Politis, P. C.; Lambrichts, L. I.] Hasselt Univ, Biomed Res Inst, Lab Funct Morphol, Hasselt, Belgium. | - |
local.publisher.place | HOBOKEN | - |
local.type.refereed | Refereed | - |
local.type.specified | Meeting Abstract | - |
dc.bibliographicCitation.oldjcat | A5 | - |
dc.identifier.isi | 000308313000294 | - |
item.fulltext | No Fulltext | - |
item.accessRights | Closed Access | - |
item.contributor | MARTENS, Wendy | - |
item.contributor | BRONCKAERS, Annelies | - |
item.contributor | HILKENS, Petra | - |
item.contributor | GERVOIS, Pascal | - |
item.contributor | POLITIS, Constantinus | - |
item.contributor | LAMBRICHTS, Ivo | - |
item.fullcitation | MARTENS, Wendy; BRONCKAERS, Annelies; HILKENS, Petra; GERVOIS, Pascal; POLITIS, Constantinus & LAMBRICHTS, Ivo (2012) Human dental pulp stem cells have a positive influence on neural regeneration. In: JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 6 (Special Issue, Supplement 1), p. 80-80. | - |
crisitem.journal.issn | 1932-6254 | - |
crisitem.journal.eissn | 1932-7005 | - |
Appears in Collections: | Research publications |
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