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Title: | Analysis of an optical biosensor based on elastic light scattering from diamond-, glass-, and sapphire microspheres | Authors: | MURIB, Mohammed Sharif Tran, Anh Quang DE CEUNINCK, Ward Schöning, J.M. NESLADEK, Milos Serpengüzel, Ali WAGNER, Patrick |
Issue Date: | 2012 | Publisher: | WILEY-V C H VERLAG GMBH | Source: | PHYSICA STATUS SOLIDI A-APPLICATIONS AND MATERIALS SCIENCE, 209 (9), p. 1804-1810 | Abstract: | Deoxyribonucleic acid (DNA) and protein recognition are now standard tools in biology. In addition, the special optical properties of microsphere resonators expressed by the high quality factor (Q-factor) of whispering gallery modes (WGMs) or morphology dependent resonances (MDRs) have attracted the attention of the biophotonic community. Microsphere-based biosensors are considered as powerful candidates to achieve label-free recognition of single molecules due to the high sensitivity of their WGMs. When the microsphere surface is modified with biomolecules, the effective refractive index and the effective size of the microsphere change resulting in a resonant wavelength shift. The transverse electric (TE) and the transverse magnetic (TM) elastic light scattering intensity of electromagnetic waves at 600 and 1400?nm are numerically calculated for DNA and unspecific binding of proteins to the microsphere surface. The effect of changing the optical properties was studied for diamond (refractive index 2.34), glass (refractive index 1.50), and sapphire (refractive index 1.75) microspheres with a 50 mu m radius. The mode spacing, the linewidth of WGMs, and the shift of resonant wavelength due to the change in radius and refractive index, were analyzed by numerical simulations. Preliminary results of unspecific binding of biomolecules are presented. The calculated shift in WGMs can be used for biomolecules detection. | Notes: | [Murib, Mohammed S.; Anh Quang Tran; De Ceuninck, Ward; Nesladek, Milos; Wagner, Patrick] Hasselt Univ, Inst Mat Res, IMO, B-3590 Diepenbeek, Belgium. [De Ceuninck, Ward; Nesladek, Milos; Wagner, Patrick] IMEC VZW, Div IMOMEC, B-3590 Diepenbeek, Belgium. [Schoening, Michael J.] Aachen Univ Appl Sci, Inst Nano & Biotechnol, D-52428 Julich, Germany. [Serpenguzel, Ali] Koc Univ, Dept Phys, Microphoton Res Lab, TR-34450 Istanbul, Turkey. mohammed.murib@uhasselt.be | Keywords: | label-free biosensors; microcavity; microsphere; morphology dependent resonance; photonics; whispering gallery mode;Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter; label-free biosensors; microcavity; microsphere; morphology dependent resonance; photonics; whispering gallery mode | Document URI: | http://hdl.handle.net/1942/14339 | ISSN: | 1862-6300 | e-ISSN: | 1862-6319 | DOI: | 10.1002/pssa.201100795 | ISI #: | 000308942100030 | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2013 |
Appears in Collections: | Research publications |
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