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http://hdl.handle.net/1942/14383
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DC Field | Value | Language |
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dc.contributor.author | SMETS, Anke | - |
dc.contributor.author | Nuydens, R. | - |
dc.contributor.author | DE JONGH, Rafael | - |
dc.contributor.author | Pintelon, I. | - |
dc.contributor.author | THYS, Isabel | - |
dc.contributor.author | Timmermans, J. P. | - |
dc.contributor.author | RIGO, Jean-Michel | - |
dc.contributor.author | MEERT, Theo | - |
dc.date.accessioned | 2012-11-16T12:17:01Z | - |
dc.date.available | 2012-11-16T12:17:01Z | - |
dc.date.issued | 2009 | - |
dc.identifier.citation | Baron, A; Chneiweiss, H (Ed.). 9TH EUROPEAN MEETING ON GLIAL CELLS IN HEALTH AND DISEASE, p. 153-156 | - |
dc.identifier.isbn | 978-88-7587-521-3 | - |
dc.identifier.uri | http://hdl.handle.net/1942/14383 | - |
dc.description.abstract | The high levels of histamine in brain after traumatic brain injury and the observed influence of histamine on aquaporin-1 (AQP-1) localization in gastric cells, lead to the hypothesis that histamine could play a major role in the pathophysiology of brain edema An intracerebroventricular (ICV) histamine induced brain edema model was developed in rats. Infusion of concentrations >= 50 mM histamine resulted in a dose-dependent intracranial pressure (ICP) increase and death. Furthermore, histological experiments showed the internalization of membrane-expressed AQP4 after histamine challenge. The decreased fraction of functional membrane-associated AQP4 might result in an increased intracranial p[ressure. In this new experimental rat mode, the functional activity of novel treatment options for increased ICP, IV or ICV administration, can readily be tested. | - |
dc.language.iso | en | - |
dc.publisher | MEDIMOND S R L | - |
dc.subject.other | Clinical Neurology; Neurosciences | - |
dc.title | The effect of histamine, a traumatic brain injury mediator, on the function of aquaporin-4 in rat brain in vivo | - |
dc.type | Proceedings Paper | - |
local.bibliographicCitation.authors | Baron, A | - |
local.bibliographicCitation.authors | Chneiweiss, H | - |
local.bibliographicCitation.conferencedate | SEP 08-12, 2009 | - |
local.bibliographicCitation.conferencename | 9th European Meeting on Glial Cells in Health and Disease | - |
local.bibliographicCitation.conferenceplace | Paris, FRANCE | - |
dc.identifier.epage | 156 | - |
dc.identifier.spage | 153 | - |
local.bibliographicCitation.jcat | C1 | - |
dc.description.notes | Address: Smets, A (reprint author), Univ Hasselt, Biomed Res Unit BIOMED, Diepenbeek, Belgium. | - |
local.publisher.place | VIA MASERATI 5, 40128 BOLOGNA, 00000, ITALY | - |
local.type.refereed | Refereed | - |
local.type.specified | Proceedings Paper | - |
dc.bibliographicCitation.oldjcat | C1 | - |
dc.identifier.isi | 000292191900030 | - |
local.bibliographicCitation.btitle | 9TH EUROPEAN MEETING ON GLIAL CELLS IN HEALTH AND DISEASE | - |
item.fullcitation | SMETS, Anke; Nuydens, R.; DE JONGH, Rafael; Pintelon, I.; THYS, Isabel; Timmermans, J. P.; RIGO, Jean-Michel & MEERT, Theo (2009) The effect of histamine, a traumatic brain injury mediator, on the function of aquaporin-4 in rat brain in vivo. In: Baron, A; Chneiweiss, H (Ed.). 9TH EUROPEAN MEETING ON GLIAL CELLS IN HEALTH AND DISEASE, p. 153-156. | - |
item.accessRights | Closed Access | - |
item.contributor | SMETS, Anke | - |
item.contributor | Nuydens, R. | - |
item.contributor | DE JONGH, Rafael | - |
item.contributor | Pintelon, I. | - |
item.contributor | THYS, Isabel | - |
item.contributor | Timmermans, J. P. | - |
item.contributor | RIGO, Jean-Michel | - |
item.contributor | MEERT, Theo | - |
item.fulltext | No Fulltext | - |
item.validation | ecoom 2012 | - |
Appears in Collections: | Research publications |
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