Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/14383
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dc.contributor.authorSMETS, Anke-
dc.contributor.authorNuydens, R.-
dc.contributor.authorDE JONGH, Rafael-
dc.contributor.authorPintelon, I.-
dc.contributor.authorTHYS, Isabel-
dc.contributor.authorTimmermans, J. P.-
dc.contributor.authorRIGO, Jean-Michel-
dc.contributor.authorMEERT, Theo-
dc.date.accessioned2012-11-16T12:17:01Z-
dc.date.available2012-11-16T12:17:01Z-
dc.date.issued2009-
dc.identifier.citationBaron, A; Chneiweiss, H (Ed.). 9TH EUROPEAN MEETING ON GLIAL CELLS IN HEALTH AND DISEASE, p. 153-156-
dc.identifier.isbn978-88-7587-521-3-
dc.identifier.urihttp://hdl.handle.net/1942/14383-
dc.description.abstractThe high levels of histamine in brain after traumatic brain injury and the observed influence of histamine on aquaporin-1 (AQP-1) localization in gastric cells, lead to the hypothesis that histamine could play a major role in the pathophysiology of brain edema An intracerebroventricular (ICV) histamine induced brain edema model was developed in rats. Infusion of concentrations >= 50 mM histamine resulted in a dose-dependent intracranial pressure (ICP) increase and death. Furthermore, histological experiments showed the internalization of membrane-expressed AQP4 after histamine challenge. The decreased fraction of functional membrane-associated AQP4 might result in an increased intracranial p[ressure. In this new experimental rat mode, the functional activity of novel treatment options for increased ICP, IV or ICV administration, can readily be tested.-
dc.language.isoen-
dc.publisherMEDIMOND S R L-
dc.subject.otherClinical Neurology; Neurosciences-
dc.titleThe effect of histamine, a traumatic brain injury mediator, on the function of aquaporin-4 in rat brain in vivo-
dc.typeProceedings Paper-
local.bibliographicCitation.authorsBaron, A-
local.bibliographicCitation.authorsChneiweiss, H-
local.bibliographicCitation.conferencedateSEP 08-12, 2009-
local.bibliographicCitation.conferencename9th European Meeting on Glial Cells in Health and Disease-
local.bibliographicCitation.conferenceplaceParis, FRANCE-
dc.identifier.epage156-
dc.identifier.spage153-
local.bibliographicCitation.jcatC1-
dc.description.notesAddress: Smets, A (reprint author), Univ Hasselt, Biomed Res Unit BIOMED, Diepenbeek, Belgium.-
local.publisher.placeVIA MASERATI 5, 40128 BOLOGNA, 00000, ITALY-
local.type.refereedRefereed-
local.type.specifiedProceedings Paper-
dc.bibliographicCitation.oldjcatC1-
dc.identifier.isi000292191900030-
local.bibliographicCitation.btitle9TH EUROPEAN MEETING ON GLIAL CELLS IN HEALTH AND DISEASE-
item.fullcitationSMETS, Anke; Nuydens, R.; DE JONGH, Rafael; Pintelon, I.; THYS, Isabel; Timmermans, J. P.; RIGO, Jean-Michel & MEERT, Theo (2009) The effect of histamine, a traumatic brain injury mediator, on the function of aquaporin-4 in rat brain in vivo. In: Baron, A; Chneiweiss, H (Ed.). 9TH EUROPEAN MEETING ON GLIAL CELLS IN HEALTH AND DISEASE, p. 153-156.-
item.accessRightsClosed Access-
item.contributorSMETS, Anke-
item.contributorNuydens, R.-
item.contributorDE JONGH, Rafael-
item.contributorPintelon, I.-
item.contributorTHYS, Isabel-
item.contributorTimmermans, J. P.-
item.contributorRIGO, Jean-Michel-
item.contributorMEERT, Theo-
item.fulltextNo Fulltext-
item.validationecoom 2012-
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