Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/14400
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Sughis, Muhammad | - |
dc.contributor.author | NAWROT, Tim | - |
dc.contributor.author | Haufroid, Vincent | - |
dc.contributor.author | Nemery, Benoit | - |
dc.date.accessioned | 2012-11-26T07:31:57Z | - |
dc.date.available | 2012-11-26T07:31:57Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | ENVIRONMENTAL HEALTH PERSPECTIVES, 120 (10), p. 1469-1474 | - |
dc.identifier.issn | 0091-6765 | - |
dc.identifier.uri | http://hdl.handle.net/1942/14400 | - |
dc.description.abstract | BACKGROUND: A considerable part of the worldwide production of surgical instruments takes place in Sialkot, Pakistan. Many children work in hazardous conditions in this industry. OBJECTIVE: We investigated exposure to metals and possible health effects among children working in surgical instruments manufacturing units compared with schoolchildren from the same city. METHODS: In a cross-sectional study we studied a convenience sample of 104 male children (10-14 years of age) working in surgical instruments manufacturing units and 75 male children of similar age from a school in Sialkot, Pakistan. A respiratory questionnaire was administered, spirometry was performed, and blood pressure was measured. In a spot urine sample, concentrations of metals were measured by inductively coupled plasma mass spectrometry and 8-hydroxydeoxyguanosine (8OHdG, reflecting oxidative DNA damage) by ELISA. RESULTS: The working children reported more asthma (10% vs. 0%; p = 0.005) and dry cough at night (36% vs. 20%; p = 0.02) than did the schoolchildren, but there were no significant differences in pulmonary function or blood pressure. The urinary concentration of chromium was 35 times higher in working children [geometric mean, 23.0 mu g/L; 25th-75th percentile, 8.38-58.6] than in schoolchildren [0.66 mu g/L; 0.38-1.09)], and largely in excess of the occupational Biological Exposure Index for adult workers (25 mu g/L). Urinary 8-OHdG concentrations were not significantly higher in working children than in schoolchildren (19.3 vs. 17.6 mu g/g creatinine, p = 0.4), but were significantly correlated with urinary nickel (r = 0.41; p < 0.0001) and with a composite index of metal exposure (r = 0.46; p < 0.0001). CONCLUSIONS: Children working in the surgical instruments manufacturing industry had substantial exposure to several metals, especially chromium and nickel, which are established carcinogens. Exposure to nickel was associated with evidence of increased oxidative DNA damage. | - |
dc.language.iso | en | - |
dc.publisher | US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE | - |
dc.subject.other | Environmental Sciences; Public, Environmental & Occupational Health; metal exposure; nickel; oxidative DNA damage; Pakistan; Sialkot; surgical instruments | - |
dc.subject.other | metal exposure; nickel; oxidative DNA damage; Pakistan; Sialkot; surgical instruments | - |
dc.title | Adverse Health Effects of Child Labor: High Exposure to Chromium and Oxidative DNA Damage in Children Manufacturing Surgical Instruments | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 1474 | - |
dc.identifier.issue | 10 | - |
dc.identifier.spage | 1469 | - |
dc.identifier.volume | 120 | - |
local.format.pages | 6 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | [Nemery, Benoit] Katholieke Univ Leuven, Dept Publ Hlth, Lab Pneumol Longtoxicol, Lung Toxicol Res Unit, B-3000 Louvain, Belgium. [Sughis, Muhammad] Ctr Res Publ Hlth, Lahore, Pakistan. [Sughis, Muhammad] Lahore Coll Pharmaceut Sci, Lahore, Pakistan. [Nawrot, Tim S.] Hasselt Univ, Ctr Environm Sci, Diepenbeek, Belgium. [Haufroid, Vincent] Catholic Univ Louvain, Louvain Ctr Toxicol & Appl Pharmacol LTAP, B-1200 Brussels, Belgium. ben.nemery@med.kuleuven.be | - |
local.publisher.place | RES TRIANGLE PK | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.bibliographicCitation.oldjcat | A1 | - |
dc.identifier.doi | 10.1289/ehp.1104678 | - |
dc.identifier.isi | 000309692600032 | - |
item.fullcitation | Sughis, Muhammad; NAWROT, Tim; Haufroid, Vincent & Nemery, Benoit (2012) Adverse Health Effects of Child Labor: High Exposure to Chromium and Oxidative DNA Damage in Children Manufacturing Surgical Instruments. In: ENVIRONMENTAL HEALTH PERSPECTIVES, 120 (10), p. 1469-1474. | - |
item.fulltext | With Fulltext | - |
item.accessRights | Open Access | - |
item.validation | ecoom 2013 | - |
item.contributor | Sughis, Muhammad | - |
item.contributor | NAWROT, Tim | - |
item.contributor | Haufroid, Vincent | - |
item.contributor | Nemery, Benoit | - |
crisitem.journal.issn | 0091-6765 | - |
crisitem.journal.eissn | 1552-9924 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
sughis 1.pdf | Published version | 720.57 kB | Adobe PDF | View/Open |
SCOPUSTM
Citations
38
checked on Sep 2, 2020
WEB OF SCIENCETM
Citations
46
checked on Sep 12, 2024
Page view(s)
86
checked on Sep 6, 2022
Download(s)
136
checked on Sep 6, 2022
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.