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http://hdl.handle.net/1942/14485
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DC Field | Value | Language |
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dc.contributor.author | VERBRUGGE, Frederik | - |
dc.contributor.author | DUPONT, Matthias | - |
dc.contributor.author | Rivero-Ayerza, Maximo | - |
dc.contributor.author | DE VUSSER, Philip | - |
dc.contributor.author | VANDERVOORT, Pieter | - |
dc.contributor.author | Van Herendael, Hugo | - |
dc.contributor.author | Vercammen, Jan | - |
dc.contributor.author | Jacobs, Linda | - |
dc.contributor.author | Verhaert, David | - |
dc.contributor.author | MULLENS, Wilfried | - |
dc.contributor.author | Tang, W. H. Wilson | - |
dc.date.accessioned | 2013-01-03T08:46:07Z | - |
dc.date.available | 2013-01-03T08:46:07Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | JOURNAL OF CARDIAC FAILURE, 18 (11), p. 845-853 | - |
dc.identifier.issn | 1071-9164 | - |
dc.identifier.uri | http://hdl.handle.net/1942/14485 | - |
dc.description.abstract | Background: The influence of comorbid conditions on ventricular remodeling, functional status, and clinical outcome after cardiac resynchronization therapy (CRT) is insufficiently elucidated. Methods and Results: The influence of different comorbid conditions on left ventricular remodeling, improvement in New York Heart Association (NYHA) functional class, hospitalizations for heart failure, and all-cause mortality after CRT implantation was analyzed in 172 consecutive patients (mean age 71 +/- 9 y), implanted from October 2008 to April 2011 in a single tertiary care hospital. During mean follow-up of 18 +/- 9 months, 21 patients died and 57 were admitted for heart failure. Left ventricular remodeling and improvement in NYHA functional class were independent from comorbidity burden. However, diabetes mellitus (hazard ratio [HR] 3.45, 95% confidence interval [CI] 1.24-9.65) and chronic kidney disease (HR 3.11, 95% CI 1.10-8.81) were predictors of all-cause mortality, and the presence of chronic obstructive pulmonary disease (HR 1.89, 95% Cl 1.02-3.53) was independently associated with heart failure admissions. Importantly, those 3 comorbid conditions had an additive negative impact on survival and heart failure admissions, even in patients with reverse left ventricular remodeling. Conclusions: Reverse ventricular remodeling and improvement in functional status after CRT implantation are independent from comorbidity burden. However, comorbid conditions remain important predictors of all-cause mortality and heart failure admissions. | - |
dc.description.sponsorship | This study is part of the Limburg Clinical Research Program (LCRP) UHasselt-ZOL-Jessa, supported by the foundation Limburg Sterk Merk (LSM), Hasselt University, Ziekenhuis Oost-Limburg and Jessa Hospital. | - |
dc.language.iso | en | - |
dc.publisher | CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS | - |
dc.subject.other | Biventricular pacing; frailty; treatment response; adverse events | - |
dc.subject.other | Cardiac & Cardiovascular Systems; biventricular pacing; frailty; treatment response; adverse events | - |
dc.title | Comorbidity Significantly Affects Clinical Outcome After Cardiac Resynchronization Therapy Regardless of Ventricular Remodeling | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 853 | - |
dc.identifier.issue | 11 | - |
dc.identifier.spage | 845 | - |
dc.identifier.volume | 18 | - |
local.format.pages | 9 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Mullens, W (reprint author),[Verbrugge, Frederik H.; Dupont, Matthias; Rivero-Ayerza, Maximo; De Vusser, Philippe; Van Herendael, Hugo; Vercammen, Jan; Jacobs, Linda; Verhaert, David; Vandervoort, Pieter; Mullens, Wilfried] Ziekenhuis Oost Limburg, Dept Cardiol, B-3600 Genk, Belgium. [Verbrugge, Frederik H.] Hasselt Univ, Doctoral Sch Med & Life Sci, Diepenbeek, Belgium. [Vandervoort, Pieter; Tang, W. H. Wilson; Mullens, Wilfried] Hasselt Univ, Fac Med & Life Sci, Biomed Res Inst, Diepetzbeek, Belgium. [Dupont, Matthias; Verhaert, David] Cleveland Clin, Inst Heart & Vasc, Dept Cardiovasc Med, Cleveland, OH 44106 USA. wilfried.mullens@zol.be | - |
local.publisher.place | PHILADELPHIA | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1016/j.cardfail.2012.09.003 | - |
dc.identifier.isi | 000311178700006 | - |
item.accessRights | Restricted Access | - |
item.contributor | VERBRUGGE, Frederik | - |
item.contributor | DUPONT, Matthias | - |
item.contributor | Rivero-Ayerza, Maximo | - |
item.contributor | DE VUSSER, Philip | - |
item.contributor | VANDERVOORT, Pieter | - |
item.contributor | Van Herendael, Hugo | - |
item.contributor | Vercammen, Jan | - |
item.contributor | Jacobs, Linda | - |
item.contributor | Verhaert, David | - |
item.contributor | MULLENS, Wilfried | - |
item.contributor | Tang, W. H. Wilson | - |
item.fulltext | With Fulltext | - |
item.fullcitation | VERBRUGGE, Frederik; DUPONT, Matthias; Rivero-Ayerza, Maximo; DE VUSSER, Philip; VANDERVOORT, Pieter; Van Herendael, Hugo; Vercammen, Jan; Jacobs, Linda; Verhaert, David; MULLENS, Wilfried & Tang, W. H. Wilson (2012) Comorbidity Significantly Affects Clinical Outcome After Cardiac Resynchronization Therapy Regardless of Ventricular Remodeling. In: JOURNAL OF CARDIAC FAILURE, 18 (11), p. 845-853. | - |
item.validation | ecoom 2013 | - |
crisitem.journal.issn | 1071-9164 | - |
crisitem.journal.eissn | 1532-8414 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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verbrugge 1.pdf Restricted Access | Published version | 453.41 kB | Adobe PDF | View/Open Request a copy |
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