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Title: Spatiotemporal dynamics of Puumala hantavirus in suburban reservoir rodent populations
Authors: Dobly, Alexandre
Yzoard, Chloe
Cochez, Christel
Ducoffre, Genevieve
AERTS, Marc 
Roels, Stefan
Heyman, Paul
Issue Date: 2012
Source: JOURNAL OF VECTOR ECOLOGY, 37 (2), p. 276-283
Abstract: The transmission of pathogens to susceptible hosts is dependent on the vector population dynamics. In Europe, bank voles (Myodes glareolus) carry Puumala hantavirus, which causes nephropathia epidemica (NE) in humans. Fluctuations in bank vole populations and epidemics in humans are correlated but the main factors influencing this relationship remain unclear. In Belgium, more NE cases are reported in spring than in autumn. There is also a higher incidence of human infections during years of large vole populations. This study aimed to better understand the link between virus prevalence in the vector, vole demography, habitat quality, and human infections. Three rodent populations in different habitats bordering Brussels city, Belgium, were studied for two years. The seroprevalence in voles was influenced first by season (higher in spring), then by vole density, vole weight (a proxy for age), and capture site but not by year or sex. Moreover, voles with large maximal distance between two captures had a high probability for Puumala seropositivity. Additionally, the local vole density showed similar temporal variations as the number of NE cases in Belgium. These results showed that, while season was the main factor influencing vole seroprevalence, it was not sufficient to explain human risks. Indeed, vole density and weight, as well as the local habitat, were essential to understanding the interactions in these host-pathogen dynamics. This can, in turn, be of importance for assessing the human risks.
Notes: [Dobly, Alexandre; Roels, Stefan] Vet & Agrochem Res Ctr CODA CERVA, B-1180 Brussels, Belgium. [Dobly, Alexandre; Yzoard, Chloe] Univ Libre Brussels, Unit Social Ecol, B-1050 Brussels, Belgium. [Cochez, Christel; Heyman, Paul] Queen Astrid Mil Hosp, Reference Lab Vector Borne Dis, B-1120 Brussels, Belgium. [Ducoffre, Genevieve] Sci Inst Publ Hlth, Epidemiol Sect, B-1050 Brussels, Belgium. [Aerts, Marc] Hasselt Univ, Interuniv Inst Biostat & Stat Bioinformat, B-3590 Diepenbeek, Belgium. [Aerts, Marc] Katholieke Univ Leuven, B-3590 Diepenbeek, Belgium.
Keywords: Multi-annual cycles; density-dependence; epidemiology; hemorrhagic fever with renal syndrome; Arvicolinae;Entomology; multi-annual cycles; density-dependence; epidemiology; hemorrhagic fever with renal syndrome; arvicolinae
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ISSN: 1081-1710
e-ISSN: 1948-7134
DOI: 10.1111/j.1948-7134.2012.00228.x
ISI #: 000311604600004
Category: A1
Type: Journal Contribution
Validations: ecoom 2013
Appears in Collections:Research publications

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