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http://hdl.handle.net/1942/14737
Title: | High susceptibility to cytomegalovirus infection of pregnant women in Flanders, Belgium | Authors: | Leuridan, E. Ieven, M. HENS, Niel Van Damme, P. |
Issue Date: | 2012 | Source: | Facts, views & vision in ObGyn, 4 (2), p. 76-81 | Abstract: | Maternal antibodies against cytomegalovirus(CMV) infection offer, to some extent, protection against congenital CMV infection. Thisstudy describesthe seroprevalence of CMV-specific IgGin 220 parturient women during pregnancy, at delivery, at 3 months after delivery and in their cord blood (Flanders,Belgium, 2006-2008).ELISA was used to measure IgG. Ofthis population, 30% had positive IgG titres. Active transplacentaltransport was confirmed with a ratio 1.15/1. Elevated maternalIgGtitre and increased parity, but not age, were significantly associated with higherseroprevalence of CMV-specific IgG in the cord blood. These data indicate a high susceptibility to CMV among fertile women.Prenatal prevention and otherstrategiesto prevent intra-uterine infection are of critical importance in a highly susceptible population. | Keywords: | cord blood; cytomegalovirus; maternal antibodies; pregnancy; seroprevalence; transplacental transport | Document URI: | http://hdl.handle.net/1942/14737 | ISSN: | 2032-0418 | e-ISSN: | 2032-0418 | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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Leuridan et al. FVVO 2012.pdf | 118.77 kB | Adobe PDF | View/Open |
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