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Title: Magnetic resonance imaging: value of diffusion-weighted imaging in differentiating benign from malignant breast lesions
Authors: Stijven, Sandra
GIELEN, Ellen 
Bevernage, Charlotte
HORVATH, Monique 
MEYLAERTS, Liesbeth 
Issue Date: 2013
Abstract: Objectives: Although magnetic resonance imaging (MRI) has a high sensitivity in the detection of tumours, there is still much discussion about its role in breast cancer detection. MRI is not yet routinely used to further characterize lesions in patients diagnosed with breast cancer. This study investigated the impact of preoperative MRI on the surgical treatment of women with biopsy proven breast cancer. The diagnostic value of preoperative MRI was compared with that of conventional imaging (mammography and ultrasonography), and the diffusion-weighted imaging technique was also evaluated. Study design: 40 women underwent conventional imaging and biopsy as part of the clinical workup. In addition, preoperative MRI was performed in each patient. The kinetics of contrast captation were monitored and apparent diffusion coefficients were calculated. All imaging findings were compared with the histopathologic results, which were used as the gold standard. Differences in tumour extent, as determined by ultrasonography, MRI and histopathology, were evaluated. Results: Contrast captation kinetics curves are mostly aspecific, while apparent diffusion coefficient values seem to correlate much better with tumour malignancy. MRI correlated more accurately with histopathological findings than ultrasonography and even revealed unsuspected multifocal and multicentric breast carcinoma in 20 patients (50%). The surgical plan of seven patients (18%) was changed as a result of the additional information provided by MRI. Conclusion: Diffusion-weighted imaging as a complementary tool to contrast captation kinetics and morphologic measurements may increase the specificity of MRI and help in differentiating between benign and malignant breast lesions. In addition, MRI yields more precise information than mammography and ultrasonography about the exact location, the extent, the multifocality or multicentricity of the tumour and can also detect possible additional tumours. Although MRI will never replace mammography (screening) or ultrasonography as a test for breast cancer in women with no high risk (e.g. BRCA 1 or 2 carriers), its use in a preoperative setting may allow more accurate staging of the disease, which in turn could result in a change in the treatment planning. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
Notes: [Stijven, Sandra] Univ Hasselt, B-3590 Diepenbeek, Belgium. [Gielen, Ellen; Bevernage, Charlotte; Horvath, Monique; Meylaerts, Liesbeth] Ziekenhuis Oost Limburg, Dept Radiol, B-3600 Genk, Belgium.
Keywords: Breast cancer; Magnetic resonance imaging; Diffusion-weighted imaging; Apparent diffusion coefficient; Surgical management;Obstetrics & Gynecology; Reproductive Biology; Breast cancer; Magnetic resonance imaging; Diffusion-weighted imaging; Apparent diffusion coefficient; Surgical management
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ISSN: 0301-2115
e-ISSN: 1872-7654
DOI: 10.1016/j.ejogrb.2012.10.029
ISI #: 000315241700019
Category: A1
Type: Journal Contribution
Validations: ecoom 2014
Appears in Collections:Research publications

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