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http://hdl.handle.net/1942/14988
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DC Field | Value | Language |
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dc.contributor.author | MULLENS, Wilfried | - |
dc.contributor.author | VANDERVOORT, Pieter | - |
dc.contributor.author | VERBRUGGE, Frederik | - |
dc.contributor.author | GRIETEN, Lars | - |
dc.contributor.author | DUPONT, Matthias | - |
dc.contributor.author | Rivero-Ayerza, Maximo | - |
dc.contributor.author | DE VUSSER, Philip | - |
dc.contributor.author | Van Herendael, Hugo | - |
dc.contributor.author | Vercammen, Jan | - |
dc.contributor.author | Jacobs, Linda | - |
dc.contributor.author | Verhaert, David | - |
dc.contributor.author | Tang, W.H.Wilson | - |
dc.date.accessioned | 2013-04-08T08:48:49Z | - |
dc.date.available | 2013-04-08T08:48:49Z | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | 32nd Annual Scientific Meeting Belgian Society of Cardiology 2013, Brussels, Belgium, January 31 - February 1, 2013 | - |
dc.identifier.uri | http://hdl.handle.net/1942/14988 | - |
dc.description.abstract | Background: The influence of comorbidity on ventricular remodelling, functional status and clinical outcome after cardiac resynchronization therapy (CRT) is insufficiently elucidated. Methods: The influence of different comorbid conditions on left ventricular remodelling, improvement in New York Heart Association (NYHA) functional class, hospitalizations for heart failure and all-cause mortality, was analysed in 172 consecutive patients (mean age 71 +/- 9 y), implanted from October 2008 to April 2011 in a single tertiary care hospital. During mean follow-up of 18 +/- 9 months, 21 patients died and 57 were admitted for heart failure. Left ventricular remodeling and improvement in NYHA functional class were independent from comorbidity burden. However, diabetes mellitus (hazard ratio [HR] 3.45, 95% confidence interval [CI] 1.24-9.65) and chronic kidney disease (HR 3.11, 95% CI 1.10-8.81) were predictors of all-cause mortality, and the presence of chronic obstructive pulmonary disease (HR 1.89, 95% Cl 1.02-3.53) was independently associated with heart failure admissions. Importantly, those 3 comorbid conditions had an additive negative impact on survival and heart failure admissions, even in patients with reverse left ventricular remodeling. Conclusions: Reverse ventricular remodeling and improvement in functional status after CRT implantation are independent from comorbidity burden. However, comorbid conditions remain important predictors of all-cause mortality and heart failure admissions. | - |
dc.language.iso | en | - |
dc.title | Comorbidity significantly affects clinical outcome after cardiac resynchronization therapy irrespectively of ventricular remodeling | - |
dc.type | Conference Material | - |
local.bibliographicCitation.conferencedate | 2013, January 3 -February 1 | - |
local.bibliographicCitation.conferencename | 32nd Annual Scientific Meeting Belgian Society of Cardiology 2013 | - |
local.bibliographicCitation.conferenceplace | Brussels, Belgium | - |
local.bibliographicCitation.jcat | C2 | - |
local.type.refereed | Refereed | - |
local.type.specified | Conference Material | - |
item.fulltext | No Fulltext | - |
item.fullcitation | MULLENS, Wilfried; VANDERVOORT, Pieter; VERBRUGGE, Frederik; GRIETEN, Lars; DUPONT, Matthias; Rivero-Ayerza, Maximo; DE VUSSER, Philip; Van Herendael, Hugo; Vercammen, Jan; Jacobs, Linda; Verhaert, David & Tang, W.H.Wilson (2013) Comorbidity significantly affects clinical outcome after cardiac resynchronization therapy irrespectively of ventricular remodeling. In: 32nd Annual Scientific Meeting Belgian Society of Cardiology 2013, Brussels, Belgium, January 31 - February 1, 2013. | - |
item.accessRights | Closed Access | - |
item.contributor | MULLENS, Wilfried | - |
item.contributor | VANDERVOORT, Pieter | - |
item.contributor | VERBRUGGE, Frederik | - |
item.contributor | GRIETEN, Lars | - |
item.contributor | DUPONT, Matthias | - |
item.contributor | Rivero-Ayerza, Maximo | - |
item.contributor | DE VUSSER, Philip | - |
item.contributor | Van Herendael, Hugo | - |
item.contributor | Vercammen, Jan | - |
item.contributor | Jacobs, Linda | - |
item.contributor | Verhaert, David | - |
item.contributor | Tang, W.H.Wilson | - |
Appears in Collections: | Research publications |
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