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http://hdl.handle.net/1942/15103
Title: | Non-Hodgkin Lymphoma after treatment with Extended dosing temozolomide and radiotherapy for a glioblastoma: A case report | Authors: | Van Ginderachter, Laura Cox, Tony Drijkoningen, Ria ACHTEN, Ruth Joosens, Eric Maes, Annelies Theunissen, Koen MEBIS, Jeroen |
Issue Date: | 2013 | Source: | Case Report Oncology, 6, p. 45-49 | Abstract: | Temozolomide (TMZ) is an alkylating agent, used for the treatment of high-grade gliomas. This case report describes the development of a non-Hodgkin lymphoma in a patient treated with extended-dose temozolomide and radiotherapy. In addition to the possible mutagenic effect of temozolomide – as described for all alkylating agents – there might have been an immunosuppressive effect of TMZ. The pathological appearance of the lymphoma as well as the presence of a grade 3 lymphopenia early in treatment supports this hypothesis. As the use of TMZ increases, the awareness that TMZ may induce secondary malignancies should increase as well. | Document URI: | http://hdl.handle.net/1942/15103 | ISSN: | 1662-6575 | e-ISSN: | 1662-6575 | DOI: | 10.1159/000346614 | Category: | A2 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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