Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/15215
Title: The Influence of Metal Stress on the Availability and Redox State of Ascorbate, and Possible Interference with Its Cellular Functions
Authors: BIELEN, An 
REMANS, Tony 
VANGRONSVELD, Jaco 
CUYPERS, Ann 
Issue Date: 2013
Publisher: MDPI AG
Source: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 14 (3), p. 6382-6413
Abstract: Worldwide, metals have been distributed to excessive levels in the environment due to industrial and agricultural activities. Plants growing on soils contaminated with excess levels of metals experience a disturbance of the cellular redox balance, which leads to an augmentation of reactive oxygen species (ROS). Even though the increased ROS levels can cause cellular damage, controlled levels play an important role in modulating signaling networks that control physiological processes and stress responses. Plants control ROS levels using their antioxidative defense system both under non-stress conditions, as well as under stress conditions such as exposure to excess metals. Ascorbate (AsA) is a well-known and important component of the plant's antioxidative system. As primary antioxidant, it can reduce ROS directly and indirectly via ascorbate peroxidase in the ascorbate-glutathione cycle. Furthermore, AsA fulfills an essential role in physiological processes, some of which are disturbed by excess metals. In this review, known direct effects of excess metals on AsA biosynthesis and functioning will be discussed, as well as the possible interference of metals with the role of AsA in physiological and biochemical processes.
Notes: Cuypers, A (reprint author); Hasselt Univ, Ctr Environm Sci, B-3590 Diepenbeek, Belgium. an.bielen@uhasselt.be; tony.remans@uhasselt.be; jaco.vangronsveld@uhasselt.be; ann.cuypers@uhasselt.be
Keywords: metals; oxidative stress; reactive oxygen species (ROS); ascorbate; cellular redox signal;Chemistry, Multidisciplinary
Document URI: http://hdl.handle.net/1942/15215
e-ISSN: 1422-0067
DOI: 10.3390/ijms14036382
ISI #: 000316609800107
Category: A1
Type: Journal Contribution
Validations: ecoom 2014
Appears in Collections:Research publications

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