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|Title:||The distinction of metabolically ‘healthy’ from metabolically ‘unhealthy’ obese children and adolescents||Authors:||BERVOETS, Liene
|Issue Date:||2013||Source:||Belgian Association for the Study of Obesity (BASO) Free Communications Meeting, UZ Brussel, Belgium, 23/02/2013||Abstract:||Background: A majority of obese children show metabolic disturbances such as impaired glucose tolerance, insulin resistance, dyslipidemia and hypertension. However, these complications are not present in every obese child. In general, healthy obesity describes the absence of any metabolic disorder including type 2 diabetes, dyslipidemia and hypertension in an obese individual (Bluher, 2010). Objective and hypothesis: The aim of our study was to identify and compare metabolically ‘healthy’ with metabolically ‘unhealthy’ obese children. It is hypothesized that an unfavourable metabolic profile, rather than a high BMI, is associated with a higher risk for type 2 diabetes and cardiovascular disease. Methods: We retrospectively analysed data from 162 obese (mean ± SD BMI SDS: 2.7 ± 0.6) children and adolescents (91 females) aged 10 to 18 years (age: 13.4 ± 1.8 yrs) who underwent an OGTT between May 2004 and January 2012. Plasma glucose, insulin, HDL-cholesterol and triglyceride concentrations were measured. Metabolically ‘healthy’ obese (MHO) children were defined as having none of the components of the MetS, whereas metabolically unhealthy obese (MUO) were defined as having at least one component of the MetS (Zimmet et al., 2007). Results: 29 (18 %) of the subjects did not have any component of the MetS. Clinical and biochemical data of MHO compared with MUO individuals are presented in table 1.Conclusion: About 20% of the studied obese children and adolescents are metabolically ‘healthy’. Metabolically ‘healthy’ obese individuals presented a significantly better glucose tolerance, insulin sensitivity, and beta-cell function compared to metabolically ‘unhealthy’ obese children. Early identification of metabolically ‘healthy’ versus ‘unhealthy’ obese children is recommended in order to provide better targeted and personalized therapies.||Notes:||References: Bluher, M. (2010). The distinction of metabolically 'healthy' from 'unhealthy' obese individuals. Curr.Opin.Lipidol., 21, 38-43. Zimmet, P., Alberti, K. G., Kaufman, F., Tajima, N., Silink, M., Arslanian, S. et al. (2007). The metabolic syndrome in children and adolescents - an IDF consensus report. Pediatr Diabetes, 8, 299-306.||Document URI:||http://hdl.handle.net/1942/15221||Category:||C2||Type:||Conference Material|
|Appears in Collections:||Research publications|
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