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http://hdl.handle.net/1942/15366
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DC Field | Value | Language |
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dc.contributor.author | Hompes, Titia | - |
dc.contributor.author | Izzi, Benedetta | - |
dc.contributor.author | Gellens, Edith | - |
dc.contributor.author | Morreels, Maarten | - |
dc.contributor.author | FIEUWS, Steffen | - |
dc.contributor.author | Pexsters, Anne | - |
dc.contributor.author | Schops, Ganel | - |
dc.contributor.author | Dom, Myriam | - |
dc.contributor.author | Van Bree, Rieta | - |
dc.contributor.author | Freson, Kathleen | - |
dc.contributor.author | Verhaeghe, Johan | - |
dc.contributor.author | Spitz, Bernard | - |
dc.contributor.author | Demyttenaere, Koen | - |
dc.contributor.author | Glover, Vivette | - |
dc.contributor.author | Van den Bergh, Bea | - |
dc.contributor.author | Allegaert, Karel | - |
dc.contributor.author | Claes, Stephan | - |
dc.date.accessioned | 2013-08-14T13:49:05Z | - |
dc.date.available | 2013-08-14T13:49:05Z | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | JOURNAL OF PSYCHIATRIC RESEARCH, 47 (7), p. 880-891 | - |
dc.identifier.issn | 0022-3956 | - |
dc.identifier.uri | http://hdl.handle.net/1942/15366 | - |
dc.description.abstract | Background: The methylation status of the human glucocorticoid receptor gene NR3C1 in newborns has been reported to be sensitive to prenatal maternal mood. This study investigates both the association between maternal cortisol and emotional state during pregnancy and the methylation state of the promoter region of NR3C1 gene. Methods: We examined 83 pregnant women. Psychological data and diurnal cortisol data were assessed to evaluate maternal stress once each trimester. DNA methylation at different loci of the NR3C1 gene, including exon 1(B), 1(D) and 1(F). was analyzed in genomic DNA from cord blood mononuclear cells. Results: Univariable analyses indicated pregnancy related anxiety to be the strongest psychological parameter throughout pregnancy. Most significant findings concerned 1(F). Particularly the methylation state of CpG9 was significantly associated with maternal emotional wellbeing. In a multivariable model the proportion of variance in methylation state of F9 explained (PVE) by pregnancy related anxiety was 7.8% (p = 0.023) during T1. Furthermore different CpG-units located at the nerve growth factor inducible protein A (NGFI-A) binding sites of 1(F) were associated with maternal anxiety [(F20.21: PC PRAQ and fear of integrity in T1: respectively PVE:8.9% and PVE:9.0%; Fear of delivery T2: PVE:8.0%, Fear of integrity T2: PVE:6.0% and STAI T2: PVE:5.9%) - (F12.13: PC PRAQ T1: PVE:6.9%, fear of integrity T2: PVE:6.0% and fear of delivery T2: PVE:8.0%)] and cortisol (F38.39: PVE:8.9%) in T2. Conclusion: These data indicate that prenatal maternal emotional state, particularly pregnancy related anxiety, are associated with the methylation state of the NR3C1 gene in the child. (C) 2013 Elsevier Ltd. All rights reserved. | - |
dc.description.sponsorship | This study is funded by the Eurocores program of the European Union. | - |
dc.language.iso | en | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.subject.other | Psychiatry | - |
dc.subject.other | Prenatal maternal emotional wellbeing; Maternal HPA axis; Methylation state NR3C1; Maternal anxiety | - |
dc.title | Investigating the influence of maternal cortisol and emotional state during pregnancy on the DNA methylation status of the glucocorticoid receptor gene (NR3C1) promoter region in cord blood | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 891 | - |
dc.identifier.issue | 7 | - |
dc.identifier.spage | 880 | - |
dc.identifier.volume | 47 | - |
local.format.pages | 12 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Hompes, T (reprint author), Univ Hosp Leuven, Dept Psychiat, B-3000 Louvain, Belgium. Katholieke Univ Leuven, Ctr Mol & Vasc Biol, B-3000 Louvain, Belgium. Katholieke Univ Leuven, Interuniv Inst Biostat & Stat Bioinformat Ctr I B, B-3000 Louvain, Belgium. Univ Hasselt, B-3500 Hasselt, Belgium. Univ Hosp Leuven, Dept Obstet & Gynaecol, B-3000 Louvain, Belgium. Univ London Imperial Coll Sci Technol & Med, Inst Reprod & Dev Biol, London W12 0NN, England. Tilburg Univ, Dept Psychol, NL-5037 AB Tilburg, Netherlands. Univ Leuven, Dept Psychol, B-3000 Louvain, Belgium. Univ Hosp Leuven, Neonatal Intens Care Unit, B-3000 Louvain, Belgium. titia.hompes@uz.kuleuven.be | - |
local.publisher.place | OXFORD | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1016/j.jpsychires.2013.03.009 | - |
dc.identifier.isi | 000319549300005 | - |
item.fullcitation | Hompes, Titia; Izzi, Benedetta; Gellens, Edith; Morreels, Maarten; FIEUWS, Steffen; Pexsters, Anne; Schops, Ganel; Dom, Myriam; Van Bree, Rieta; Freson, Kathleen; Verhaeghe, Johan; Spitz, Bernard; Demyttenaere, Koen; Glover, Vivette; Van den Bergh, Bea; Allegaert, Karel & Claes, Stephan (2013) Investigating the influence of maternal cortisol and emotional state during pregnancy on the DNA methylation status of the glucocorticoid receptor gene (NR3C1) promoter region in cord blood. In: JOURNAL OF PSYCHIATRIC RESEARCH, 47 (7), p. 880-891. | - |
item.contributor | Hompes, Titia | - |
item.contributor | Izzi, Benedetta | - |
item.contributor | Gellens, Edith | - |
item.contributor | Morreels, Maarten | - |
item.contributor | FIEUWS, Steffen | - |
item.contributor | Pexsters, Anne | - |
item.contributor | Schops, Ganel | - |
item.contributor | Dom, Myriam | - |
item.contributor | Van Bree, Rieta | - |
item.contributor | Freson, Kathleen | - |
item.contributor | Verhaeghe, Johan | - |
item.contributor | Spitz, Bernard | - |
item.contributor | Demyttenaere, Koen | - |
item.contributor | Glover, Vivette | - |
item.contributor | Van den Bergh, Bea | - |
item.contributor | Allegaert, Karel | - |
item.contributor | Claes, Stephan | - |
item.accessRights | Restricted Access | - |
item.validation | ecoom 2014 | - |
item.fulltext | With Fulltext | - |
crisitem.journal.issn | 0022-3956 | - |
crisitem.journal.eissn | 1879-1379 | - |
Appears in Collections: | Research publications |
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