Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/15413
Title: Physiological implications of arteriovenous anastomoses and venous hemodynamic dysfunction in early gestational uterine circulation: a review
Authors: GYSELAERS, Wilfried 
Peeters, Louis
Issue Date: 2013
Publisher: INFORMA HEALTHCARE
Source: JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, 26 (9), p. 841-846
Abstract: This review summarizes current information on anatomical and physiological properties of the early gestational uteroplacental circulation, and implications of normal or abnormal functioning of the venous compartment. It is illustrated that these properties serve intra-uterine redistribution of blood flow, which is a crucial activity during different stages of trophoblastic remodelling of spiral arteries. Maintaining conditions of pressure and flow constant in the developing intervillous space is important towards normal functioning of the placenta in advanced pregnancy. Failure of this process predisposes to damage of trophoblastic villi, which is commonly seen in preeclampsia and/or fetal growth restriction. Basic principles of vascular physiology allow linking venous hemodynamic dysfunction to increased intervillous pressure. From this, it is concluded that current methods to explore the uteroplacental circulation in normal pregnancy and preeclampsia should be expanded with integrative methods focussing on each site of the microvascular network, the arterial and the venous compartment.
Notes: Gyselaers, W (reprint author), Ziekenhuis Oost Limburg, Dept Obstet & Gynaecol, B-3600 Genk, Belgium. Hasselt Univ, Dept Physiol, Diepenbeek, Belgium. Univ Med Ctr, Dept Obstet & Gynaecol, Maastricht, Netherlands. wilfried.gyselaers@zol.be
Keywords: Obstetrics & Gynecology Fetal growth restriction; gestational physiology; intervillous space; maternal veins; preeclampsia;Fetal growth restriction; gestational physiology; intervillous space; maternal veins; preeclampsia
Document URI: http://hdl.handle.net/1942/15413
ISSN: 1476-7058
e-ISSN: 1476-4954
DOI: 10.3109/14767058.2013.766705
ISI #: 000319130800001
Category: A1
Type: Journal Contribution
Validations: ecoom 2014
Appears in Collections:Research publications

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