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http://hdl.handle.net/1942/15462
Title: | Herpes Zoster Risk Reduction through Exposure to Chickenpox Patients: A Systematic Multidisciplinary Review | Authors: | OGUNJIMI, Benson Van Damme, Pierre Beutels, Philippe |
Issue Date: | 2013 | Publisher: | PUBLIC LIBRARY SCIENCE | Source: | PLOS ONE, 8 (6) | Abstract: | Varicella-zoster virus (VZV) causes chickenpox and may subsequently reactivate to cause herpes zoster later in life. The exogenous boosting hypothesis states that re-exposure to circulating VZV can inhibit VZV reactivation and consequently also herpes zoster in VZV-immune individuals. Using this hypothesis, mathematical models predicted widespread chickenpox vaccination to increase herpes zoster incidence over more than 30 years. Some countries have postponed universal chickenpox vaccination, at least partially based on this prediction. After a systematic search and selection procedure, we analyzed different types of exogenous boosting studies. We graded 13 observational studies on herpes zoster incidence after widespread chickenpox vaccination, 4 longitudinal studies on VZV immunity after re-exposure, 9 epidemiological risk factor studies, 7 mathematical modeling studies as well as 7 other studies. We conclude that exogenous boosting exists, although not for all persons, nor in all situations. Its magnitude is yet to be determined adequately in any study field. | Notes: | [Ogunjimi, Benson; Beutels, Philippe] Univ Antwerp, Ctr Hlth Econ Res & Modeling Infect Dis, Vaccine & Infect Dis Inst, B-2020 Antwerp, Belgium. [Ogunjimi, Benson] Hasselt Univ, Interuniv Inst Biostat & Stat Bioinformat, Hasselt, Belgium. [Van Damme, Pierre] Univ Antwerp, Vaccine & Infect Dis Inst, Ctr Evaluat Vaccinat, B-2020 Antwerp, Belgium. [Beutels, Philippe] Univ New S Wales, Sch Publ Hlth & Community Med, Sydney, NSW, Australia. benson.ogunjimi@ua.ac.be | Keywords: | Multidisciplinary Sciences | Document URI: | http://hdl.handle.net/1942/15462 | ISSN: | 1932-6203 | e-ISSN: | 1932-6203 | DOI: | 10.1371/journal.pone.0066485 | ISI #: | 000320846500052 | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2014 |
Appears in Collections: | Research publications |
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