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http://hdl.handle.net/1942/15482
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DC Field | Value | Language |
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dc.contributor.author | BIESMANS, Steven | - |
dc.contributor.author | MEERT, Theo | - |
dc.contributor.author | Bouwknecht, Jan A. | - |
dc.contributor.author | Acton, Paul D. | - |
dc.contributor.author | DAVOODI, Nima | - |
dc.contributor.author | De Haes, Patrick | - |
dc.contributor.author | KUIJLAARS, Jacobine | - |
dc.contributor.author | Langlois, Xavier | - |
dc.contributor.author | Matthews, Liam J. R. | - |
dc.contributor.author | Donck, Luc Ver | - |
dc.contributor.author | HELLINGS, Niels | - |
dc.contributor.author | Nuydens, Rony | - |
dc.date.accessioned | 2013-08-30T11:35:24Z | - |
dc.date.available | 2013-08-30T11:35:24Z | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | MEDIATORS OF INFLAMMATION, 2013, (ART N° 271359) | - |
dc.identifier.issn | 0962-9351 | - |
dc.identifier.uri | http://hdl.handle.net/1942/15482 | - |
dc.description.abstract | Substantial evidence indicates an association between clinical depression and altered immune function. Systemic administration of bacterial lipopolysaccharide (LPS) is commonly used to study inflammation-associated behavioral changes in rodents. In these experiments, we tested the hypothesis that peripheral immune activation leads to neuroinflammation and depressive-like behavior in mice. We report that systemic administration of LPS induced astrocyte activation in transgenic GFAP-luc mice and increased immunoreactivity against the microglial marker ionized calcium-binding adapter molecule 1 in the dentate gyrus of wild-type mice. Furthermore, LPS treatment caused a strong but transient increase in cytokine levels in the serum and brain. In addition to studying LPS-induced neuroinflammation, we tested whether sickness could be separated from depressive-like behavior by evaluating LPS-treated mice in a panel of behavioral paradigms. Our behavioral data indicate that systemic LPS administration caused sickness and mild depressive-like behavior. However, due to the overlapping time course and mild effects on depression-related behavior per se, it was not possible to separate sickness from depressive-like behavior in the present rodent model. | - |
dc.language.iso | en | - |
dc.publisher | HINDAWI PUBLISHING CORPORATION | - |
dc.subject.other | Cell Biology; Immunology | - |
dc.title | Systemic Immune Activation Leads to Neuroinflammation and Sickness Behavior in Mice | - |
dc.type | Journal Contribution | - |
dc.identifier.volume | 2013 | - |
local.format.pages | 14 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | [Biesmans, Steven; Meert, Theo F.; Davoodi, Nima; Hellings, Niels] Hasselt Univ, BIOMED, B-3590 Diepenbeek, Belgium. [Biesmans, Steven; Meert, Theo F.; Bouwknecht, Jan A.; Davoodi, Nima; De Haes, Patrick; Kuijlaars, Jacobine; Langlois, Xavier; Matthews, Liam J. R.; Donck, Luc Ver; Nuydens, Rony] Janssen Res & Dev, Div Janssen Pharmaceut NV, Neurosci, B-2340 Beerse, Belgium. [Acton, Paul D.] Janssen Res & Dev LLC, Mol Imaging, Spring House, PA 19477 USA. | - |
local.publisher.place | NEW YORK | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | 271359 | - |
dc.identifier.doi | 10.1155/2013/271359 | - |
dc.identifier.isi | 000322395400001 | - |
item.validation | ecoom 2014 | - |
item.fulltext | With Fulltext | - |
item.contributor | BIESMANS, Steven | - |
item.contributor | MEERT, Theo | - |
item.contributor | Bouwknecht, Jan A. | - |
item.contributor | Acton, Paul D. | - |
item.contributor | DAVOODI, Nima | - |
item.contributor | De Haes, Patrick | - |
item.contributor | KUIJLAARS, Jacobine | - |
item.contributor | Langlois, Xavier | - |
item.contributor | Matthews, Liam J. R. | - |
item.contributor | Donck, Luc Ver | - |
item.contributor | HELLINGS, Niels | - |
item.contributor | Nuydens, Rony | - |
item.accessRights | Open Access | - |
item.fullcitation | BIESMANS, Steven; MEERT, Theo; Bouwknecht, Jan A.; Acton, Paul D.; DAVOODI, Nima; De Haes, Patrick; KUIJLAARS, Jacobine; Langlois, Xavier; Matthews, Liam J. R.; Donck, Luc Ver; HELLINGS, Niels & Nuydens, Rony (2013) Systemic Immune Activation Leads to Neuroinflammation and Sickness Behavior in Mice. In: MEDIATORS OF INFLAMMATION, 2013, (ART N° 271359). | - |
crisitem.journal.issn | 0962-9351 | - |
crisitem.journal.eissn | 1466-1861 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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biesmans 1.pdf | Published version | 2.03 MB | Adobe PDF | View/Open |
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