Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/15482
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dc.contributor.authorBIESMANS, Steven-
dc.contributor.authorMeert, Theo F.-
dc.contributor.authorBouwknecht, Jan A.-
dc.contributor.authorActon, Paul D.-
dc.contributor.authorDAVOODI, Nima-
dc.contributor.authorDe Haes, Patrick-
dc.contributor.authorKUIJLAARS, Jacobine-
dc.contributor.authorLanglois, Xavier-
dc.contributor.authorMatthews, Liam J. R.-
dc.contributor.authorDonck, Luc Ver-
dc.contributor.authorHELLINGS, Niels-
dc.contributor.authorNuydens, Rony-
dc.date.accessioned2013-08-30T11:35:24Z-
dc.date.available2013-08-30T11:35:24Z-
dc.date.issued2013-
dc.identifier.citationMEDIATORS OF INFLAMMATION, 2013, (ART N° 271359)-
dc.identifier.issn0962-9351-
dc.identifier.urihttp://hdl.handle.net/1942/15482-
dc.description.abstractSubstantial evidence indicates an association between clinical depression and altered immune function. Systemic administration of bacterial lipopolysaccharide (LPS) is commonly used to study inflammation-associated behavioral changes in rodents. In these experiments, we tested the hypothesis that peripheral immune activation leads to neuroinflammation and depressive-like behavior in mice. We report that systemic administration of LPS induced astrocyte activation in transgenic GFAP-luc mice and increased immunoreactivity against the microglial marker ionized calcium-binding adapter molecule 1 in the dentate gyrus of wild-type mice. Furthermore, LPS treatment caused a strong but transient increase in cytokine levels in the serum and brain. In addition to studying LPS-induced neuroinflammation, we tested whether sickness could be separated from depressive-like behavior by evaluating LPS-treated mice in a panel of behavioral paradigms. Our behavioral data indicate that systemic LPS administration caused sickness and mild depressive-like behavior. However, due to the overlapping time course and mild effects on depression-related behavior per se, it was not possible to separate sickness from depressive-like behavior in the present rodent model.-
dc.language.isoen-
dc.publisherHINDAWI PUBLISHING CORPORATION-
dc.subject.otherCell Biology; Immunology-
dc.titleSystemic Immune Activation Leads to Neuroinflammation and Sickness Behavior in Mice-
dc.typeJournal Contribution-
dc.identifier.volume2013-
local.format.pages14-
local.bibliographicCitation.jcatA1-
dc.description.notes[Biesmans, Steven; Meert, Theo F.; Davoodi, Nima; Hellings, Niels] Hasselt Univ, BIOMED, B-3590 Diepenbeek, Belgium. [Biesmans, Steven; Meert, Theo F.; Bouwknecht, Jan A.; Davoodi, Nima; De Haes, Patrick; Kuijlaars, Jacobine; Langlois, Xavier; Matthews, Liam J. R.; Donck, Luc Ver; Nuydens, Rony] Janssen Res & Dev, Div Janssen Pharmaceut NV, Neurosci, B-2340 Beerse, Belgium. [Acton, Paul D.] Janssen Res & Dev LLC, Mol Imaging, Spring House, PA 19477 USA.-
local.publisher.placeNEW YORK-
local.type.refereedRefereed-
local.type.specifiedArticle-
local.bibliographicCitation.artnr271359-
dc.identifier.doi10.1155/2013/271359-
dc.identifier.isi000322395400001-
item.fullcitationBIESMANS, Steven; Meert, Theo F.; Bouwknecht, Jan A.; Acton, Paul D.; DAVOODI, Nima; De Haes, Patrick; KUIJLAARS, Jacobine; Langlois, Xavier; Matthews, Liam J. R.; Donck, Luc Ver; HELLINGS, Niels & Nuydens, Rony (2013) Systemic Immune Activation Leads to Neuroinflammation and Sickness Behavior in Mice. In: MEDIATORS OF INFLAMMATION, 2013, (ART N° 271359).-
item.fulltextWith Fulltext-
item.accessRightsOpen Access-
item.validationecoom 2014-
item.contributorLanglois, Xavier-
item.contributorDAVOODI, Nima-
item.contributorKUIJLAARS, Jacobine-
item.contributorBouwknecht, Jan A.-
item.contributorDe Haes, Patrick-
item.contributorDonck, Luc Ver-
item.contributorMeert, Theo F.-
item.contributorBIESMANS, Steven-
item.contributorMatthews, Liam J. R.-
item.contributorNuydens, Rony-
item.contributorActon, Paul D.-
item.contributorHELLINGS, Niels-
crisitem.journal.issn0962-9351-
crisitem.journal.eissn1466-1861-
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