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http://hdl.handle.net/1942/15487
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DC Field | Value | Language |
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dc.contributor.author | CUYPERS, Koen | - |
dc.contributor.author | LEENUS, Daphnie | - |
dc.contributor.author | VAN WIJMEERSCH, Bart | - |
dc.contributor.author | THIJS, Herbert | - |
dc.contributor.author | Levin, Oron | - |
dc.contributor.author | Swinnen, Stephan | - |
dc.contributor.author | MEESEN, Raf | - |
dc.date.accessioned | 2013-09-18T12:10:49Z | - |
dc.date.available | 2013-09-18T12:10:49Z | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | NEUROSCIENCE LETTERS, 554, p.151–155 | - |
dc.identifier.issn | 0304-3940 | - |
dc.identifier.uri | http://hdl.handle.net/1942/15487 | - |
dc.description.abstract | The application of anodal transcranial direct current stimulation (atDCS) to the human brain has been shown to elicit corticospinal (CS) excitability changes. This study evaluated the effect of a single session of atDCS on CS excitability in patients with multiple sclerosis (MS). atDCS and sham tDCS (stDCS) were applied to the primary motor cortex (M1) contralateral to the more severely impaired hand for 20 minutes in a double-blinded crossover design. Changes in CS excitability were assessed using transcranial magnetic stimulation (TMS). The area under the recruitment curves increased significantly after application of atDCS (+ 56.58%, p = 0.023) but not after stDCS. A sigmoidal curve- analysis revealed a higher plateau of the curve after atDCS (+22.2%, p < 0.001). Our results showed that atDCS over M1 has the ability to increase CS output and projection strength in MS-patients, suggesting that atDCS can be considered during neural rehabilitation to facilitate motor recovery in MS. | - |
dc.description.sponsorship | Financial support was available through a grant from the Flanders Fund for Scientific Research (contract G.0758.10). Koen Cuypers is supported by the Special Research Fund UHasselt. | - |
dc.language.iso | en | - |
dc.subject.other | Multiple sclerosis; tDCS; TMS; Corticospinal excitability; Recruitment curve | - |
dc.title | Anodal tDCS increases corticospinal output and projection strength in multiple sclerosis | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 155 | - |
dc.identifier.spage | 151 | - |
dc.identifier.volume | 554 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Meesen, RLJ (reprint author), Hasselt Univ, REVAL Res Inst, Agoralaan,Bldg A, B-3590 Diepenbeek, Belgium. E-mail Addresses:koen.cuypers@uhasselt.be | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1016/j.neulet.2013.09.004 | - |
dc.identifier.isi | 000327674600029 | - |
item.fulltext | With Fulltext | - |
item.validation | ecoom 2014 | - |
item.accessRights | Restricted Access | - |
item.fullcitation | CUYPERS, Koen; LEENUS, Daphnie; VAN WIJMEERSCH, Bart; THIJS, Herbert; Levin, Oron; Swinnen, Stephan & MEESEN, Raf (2013) Anodal tDCS increases corticospinal output and projection strength in multiple sclerosis. In: NEUROSCIENCE LETTERS, 554, p.151–155. | - |
item.contributor | CUYPERS, Koen | - |
item.contributor | LEENUS, Daphnie | - |
item.contributor | VAN WIJMEERSCH, Bart | - |
item.contributor | THIJS, Herbert | - |
item.contributor | Levin, Oron | - |
item.contributor | Swinnen, Stephan | - |
item.contributor | MEESEN, Raf | - |
crisitem.journal.issn | 0304-3940 | - |
crisitem.journal.eissn | 1872-7972 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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Meesen.pdf Restricted Access | 561.65 kB | Adobe PDF | View/Open Request a copy |
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