Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/15509
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dc.contributor.authorVERBRUGGE, Frederik-
dc.contributor.authorDUPONT, Matthias-
dc.contributor.authorSTEELS, Paul-
dc.contributor.authorGRIETEN, Lars-
dc.contributor.authorMalbrain, Manu L. N.-
dc.contributor.authorTang, W. H. Wilson-
dc.contributor.authorMULLENS, Wilfried-
dc.date.accessioned2013-09-25T13:23:03Z-
dc.date.available2013-09-25T13:23:03Z-
dc.date.issued2013-
dc.identifier.citationJOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 62 (6), p. 485-495-
dc.identifier.issn0735-1097-
dc.identifier.urihttp://hdl.handle.net/1942/15509-
dc.description.abstractCurrent pathophysiological models of congestive heart failure unsatisfactorily explain the detrimental link between congestion and cardiorenal function. Abdominal congestion (i.e., splanchnic venous and interstitial congestion) manifests in a substantial number of patients with advanced congestive heart failure, yet is poorly defined. Compromised capacitance function of the splanchnic vasculature and deficient abdominal lymph flow resulting in interstitial edema might both be implied in the occurrence of increased cardiac filling pressures and renal dysfunction. Indeed, increased intra-abdominal pressure, as an extreme marker of abdominal congestion, is correlated with renal dysfunction in advanced congestive heart failure. Intriguing findings provide preliminary evidence that alterations in the liver and spleen contribute to systemic congestion in heart failure. Finally, gut-derived hormones might influence sodium homeostasis, whereas entrance of bowel toxins into the circulatory system, as a result of impaired intestinal barrier function secondary to congestion, might further depress cardiac as well as renal function. Those toxins are mainly produced by micro-organisms in the gut lumen, with presumably important alterations in advanced heart failure, especially when renal function is depressed. Therefore, in this state-of-the-art review, we explore the crosstalk between the abdomen, heart, and kidneys in congestive heart failure. This might offer new diagnostic opportunities as well as treatment strategies to achieve decongestion in heart failure, especially when abdominal congestion is present. Among those currently under investigation are paracentesis, ultrafiltration, peritoneal dialysis, oral sodium binders, vasodilator therapy, renal sympathetic denervation and agents targeting the gut microbiota. (J Am Coll Cardiol 2013;62:485-95) (C) 2013 by the American College of Cardiology Foundation-
dc.language.isoen-
dc.publisherELSEVIER SCIENCE INC-
dc.subject.othercongestive heart failure; gut; microcirculation; splanchnic circulation-
dc.subject.otherCardiac & Cardiovascular Systems-
dc.titleAbdominal Contributions to Cardiorenal Dysfunction in Congestive Heart Failure-
dc.typeJournal Contribution-
dc.identifier.epage495-
dc.identifier.issue6-
dc.identifier.spage485-
dc.identifier.volume62-
local.format.pages11-
local.bibliographicCitation.jcatA1-
dc.description.notes[Verbrugge, Frederik H.; Dupont, Matthias; Grieten, Lars; Mullens, Wilfried] Ziekenhuis Oost Limburg, Dept Cardiol, B-3600 Genk, Belgium. [Verbrugge, Frederik H.] Hasselt Univ, Doctoral Sch Med & Life Sci, Diepenbeek, Belgium. [Steels, Paul; Grieten, Lars; Mullens, Wilfried] Hasselt Univ, Fac Med & Life Sci, Biomed Res Inst, Diepenbeek, Belgium. [Malbrain, Manu] Ziekenhuis Netwerk Antwerpen, Intens Care & High Care Burn Unit, Antwerp, Belgium. [Tang, W. H. Wilson] Cleveland Clin, Dept Cardiovasc Med, Inst Heart & Vasc, Cleveland, OH 44106 USA.-
local.publisher.placeNEW YORK-
local.type.refereedRefereed-
local.type.specifiedReview-
dc.identifier.doi10.1016/j.jacc.2013.04.070-
dc.identifier.isi000322524300002-
item.accessRightsOpen Access-
item.fulltextWith Fulltext-
item.validationecoom 2014-
item.contributorVERBRUGGE, Frederik-
item.contributorDUPONT, Matthias-
item.contributorSTEELS, Paul-
item.contributorGRIETEN, Lars-
item.contributorMalbrain, Manu L. N.-
item.contributorTang, W. H. Wilson-
item.contributorMULLENS, Wilfried-
item.fullcitationVERBRUGGE, Frederik; DUPONT, Matthias; STEELS, Paul; GRIETEN, Lars; Malbrain, Manu L. N.; Tang, W. H. Wilson & MULLENS, Wilfried (2013) Abdominal Contributions to Cardiorenal Dysfunction in Congestive Heart Failure. In: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 62 (6), p. 485-495.-
crisitem.journal.issn0735-1097-
crisitem.journal.eissn1558-3597-
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