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http://hdl.handle.net/1942/15510
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DC Field | Value | Language |
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dc.contributor.author | ROUWETTE, Myrthe | - |
dc.contributor.author | NOBEN, Jean-Paul | - |
dc.contributor.author | VAN HORSSEN, Jack | - |
dc.contributor.author | VAN WIJMEERSCH, Bart | - |
dc.contributor.author | Hupperts, Raymond | - |
dc.contributor.author | Jongen, Peter J. | - |
dc.contributor.author | Verbeek, Marcel M. | - |
dc.contributor.author | De Deyn, Peter P. | - |
dc.contributor.author | STINISSEN, Piet | - |
dc.contributor.author | SOMERS, Veerle | - |
dc.date.accessioned | 2013-09-25T13:28:14Z | - |
dc.date.available | 2013-09-25T13:28:14Z | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | JOURNAL OF NEUROCHEMISTRY, 126 (4), p. 483-492 | - |
dc.identifier.issn | 0022-3042 | - |
dc.identifier.uri | http://hdl.handle.net/1942/15510 | - |
dc.description.abstract | Recently, we identified the mimotope UH-CIS6 as a novel candidate antibody target for clinically isolated syndrome (CIS) and relapsing-remitting (RR) multiple sclerosis (MS). The purpose of this study was to further validate UH-CIS6 as an antibody target for CIS and MS and to identify the in vivo antibody target of UH-CIS6. First, a UH-CIS6 peptide ELISA was optimized. Next, we investigated the antibody response toward UH-CIS6 in cerebrospinal fluid (CSF) from patients with CIS (n = 20), MS (n = 43) and other neurological diseases (n = 42). Immunoprecipitation of anti-UH-CIS6 antibodies on a normal human brain lysate was performed to identify the in vivo antibody target of UH-CIS6. The cellular expression of an in vivo candidate target was investigated by immunohistochemistry using MS brain tissue sections. Antibody reactivity toward UH-CIS6 was detected in a significantly increased proportion of CSF samples from CIS and RR-MS patients as compared with neurological controls (p = 0.046). We identified and confirmed coronin-1a as the in vivo antibody target for UH-CIS6. Furthermore, coronin-1a was expressed by T cells and macrophages in an active MS lesion. Together, these results demonstrate that coronin-1a is a novel antibody target for CIS and MS. | - |
dc.language.iso | en | - |
dc.title | Identification of coronin-1a as a novel antibody target for clinically isolated syndrome and multiple sclerosis | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 492 | - |
dc.identifier.issue | 4 | - |
dc.identifier.spage | 483 | - |
dc.identifier.volume | 126 | - |
local.bibliographicCitation.jcat | A1 | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1111/jnc.12335 | - |
dc.identifier.isi | 000322721600007 | - |
item.accessRights | Restricted Access | - |
item.validation | ecoom 2014 | - |
item.fulltext | With Fulltext | - |
item.fullcitation | ROUWETTE, Myrthe; NOBEN, Jean-Paul; VAN HORSSEN, Jack; VAN WIJMEERSCH, Bart; Hupperts, Raymond; Jongen, Peter J.; Verbeek, Marcel M.; De Deyn, Peter P.; STINISSEN, Piet & SOMERS, Veerle (2013) Identification of coronin-1a as a novel antibody target for clinically isolated syndrome and multiple sclerosis. In: JOURNAL OF NEUROCHEMISTRY, 126 (4), p. 483-492. | - |
item.contributor | ROUWETTE, Myrthe | - |
item.contributor | NOBEN, Jean-Paul | - |
item.contributor | VAN HORSSEN, Jack | - |
item.contributor | VAN WIJMEERSCH, Bart | - |
item.contributor | Hupperts, Raymond | - |
item.contributor | Jongen, Peter J. | - |
item.contributor | Verbeek, Marcel M. | - |
item.contributor | De Deyn, Peter P. | - |
item.contributor | STINISSEN, Piet | - |
item.contributor | SOMERS, Veerle | - |
crisitem.journal.issn | 0022-3042 | - |
crisitem.journal.eissn | 1471-4159 | - |
Appears in Collections: | Research publications |
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rouwette 1.pdf Restricted Access | Published version | 601.89 kB | Adobe PDF | View/Open Request a copy |
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