Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/15784
Title: Establishment of reference values for novel urinary biomarkers for renal damage in the healthy population: are age and gender an issue?
Authors: PENNEMANS, Valerie 
RIGO, Jean-Michel 
FAES, Christel 
Reynders, Carmen
PENDERS, Joris 
SWENNEN, Quirine 
Issue Date: 2013
Source: CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 51 (9), p. 1795-1802
Abstract: Background: Recently, a lot of research has focused on the discovery of novel renal biomarkers. Among others, the urinary kidney injury molecule 1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) have been proven to be promising biomarkers in a wide variety of renal pathologies. However, little is known about the normal concentrations in urine of healthy subjects. Therefore, the goal of our study is to establish reference values for urinary KIM-1, NGAL, N-acetyl-beta-D-glucosamidase (NAG), and cystatin C in a healthy population, taking into account possible effects of age and gender. Methods: We collected urine samples from 338 healthy, nonsmoking subjects between 0 and 95 years old. Subjects with elevated alpha 1-microglobulin values were excluded. Next to the urinary concentrations of KIM-1, NGAL, NAG, and cystatin C, we measured urinary creatinine and specific gravity to correct for urinary dilution. The possible effect of age and gender on the four urinary biomarkers was investigated, and the reference values were established. Results: For the absolute urinary concentrations of the biomarkers, age had a significant effect on all the biomarkers, except for cystatin C, whereas gender significantly affected all four of them, except for NAG. The normalization of biomarkers for creatinine and specific gravity had an effect on the correlation between the biomarkers on one hand and age and gender on the other. Conclusions: In conclusion, age and gender had different effects on KIM-1, NGAL, NAG, and cystatin C. Based on this knowledge, age-and gender-specific reference values for KIM-1, NGAL, NAG, and cystatin C were established.
Notes: Pennemans, V (reprint author), Biomed Res Inst, Agoralaan,Gebouw C, B-3590 Diepenbeek, Belgium, valerie.pennemans@uhasselt.be
Keywords: Conclusions: In conclusion, age and gender had different effects on KIM-1, NGAL, NAG, and cystatin C. Based on this knowledge, age-and gender-specific reference values for KIM-1, NGAL, NAG, and cystatin C were established.
Document URI: http://hdl.handle.net/1942/15784
ISSN: 1434-6621
e-ISSN: 1437-4331
DOI: 10.1515/cclm-2013-0157
ISI #: 000324177500023
Category: A1
Type: Journal Contribution
Validations: ecoom 2014
Appears in Collections:Research publications

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