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http://hdl.handle.net/1942/15825
Title: | Bimanual motor deficits in older adults predicted by diffusion tensor imaging metrics of corpus callosum subregions | Authors: | Serbruyns, Leen Gooijers, Jolien Caeyenberghs, Karen MEESEN, Raf CUYPERS, Koen Sisti, Helene Alexander, Leemans Swinnen, Stephan |
Issue Date: | 2013 | Source: | Brain Structure & Function, 220 (1), p. 273-290 | Abstract: | Age-related changes in the microstructural organization of the corpus callosum (CC) may explain declines in bimanual motor performance associated with normal aging. We used diffusion tensor imaging in young (n = 33) and older (n = 33) adults to investigate the microstructural organization of seven specific CC subregions (prefrontal, premotor, primary motor, primary sensory, parietal, temporal and occipital). A set of bimanual tasks was used to assess various aspects of bimanual motor functioning: the Purdue Pegboard test, simultaneous and alternating finger tapping, a choice reaction time test and a complex visuomotor tracking task. The older adults showed age-related deficits on all measures of bimanual motor performance. Correlation analyses within the older group showed that white matter fractional anisotropy of the CC occipital region was associated with bimanual fine manipulation skills (Purdue Pegboard test), whereas better performance on the other bimanual tasks was related to higher fractional anisotropy in the more anterior premotor, primary motor and primary sensory CC subregions. Such associations were less prominent in the younger group. Our findings suggest that structural alterations of subregional callosal fibers may account for bimanual motor declines in normal aging. | Notes: | Swinnen, SP (reprint author), Katholieke Univ Leuven, Biomed Sci Grp, Movement Control & Neuroplast Res Grp, Motor Control Lab, Tervuursevest 101, B-3001 Heverlee, Belgium. Stephan.Swinnen@faber.kuleuven.be | Keywords: | Aging; Bimanual coordination; Corpus callosum; DTI; Fractional anisotropy | Document URI: | http://hdl.handle.net/1942/15825 | ISSN: | 1863-2653 | e-ISSN: | 1863-2661 | DOI: | 10.1007/s00429-013-0654-z | ISI #: | 000348980800020 | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2016 |
Appears in Collections: | Research publications |
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meesen.pdf Restricted Access | Published version | 1.03 MB | Adobe PDF | View/Open Request a copy |
Pdf_geheel.pdf | Peer-reviewed author version | 777.29 kB | Adobe PDF | View/Open |
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