Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/15913
Title: A single session of 1mA anodal tDCS-supported motor training does not improve motor performance in patients with multiple sclerosis.
Authors: MEESEN, Raf 
THIJS, Herbert 
LEENUS, Daphnie 
CUYPERS, Koen 
Issue Date: 2014
Source: RESTORATIVE NEUROLOGY AND NEUROSCIENCE 32 (2), 293-300
Abstract: Purpose: To assess the effects of atDCS on motor performance in patients with multiple sclerosis (MS). Previously, anodal transcranial direct current stimulation (atDCS) has been shown to improve motor performance in healthy subjects and neurodegenerative populations. However, the effect of atDCS on motor performance is not examined in MS. Methods: In the current study, a sham controlled double-blind crossover design was used to evaluate the effect of 20 minutes of 1mA atDCS or sham tDCS (stDCS) on a unimanual motor sequence-training task, consisting of sequential finger presses on a computer keyboard with the most impaired hand. Patients received stimulation (atDCS or stDCS) during motor training. tDCS was applied over the primary motor cortex contralateral to the most impaired hand. Motor performance was assessed immediately before, during and 30 minutes after stimulation. Results: Although we need to be careful with the interpretation of the data due to lack of power, our results showed no significant effect of atDCS on motor performance. Conclusions: Our findings indicate that atDCS-supported motor training was not able to improve motor performance more than sham-supported motor training. Possibly, the effects of atDCS are mediated by specific MS-related characteristics. Furthermore, increasing atDCS intensity and offering multiple stimulation sessions might be necessary to optimize motor performance resulting from atDCS-supported motor training.
Notes: Cuypers, K (reprint author), Hasselt Univ, REVAL Res Inst, Agoralaan,Bldg A, B-3590 Diepenbeek, Belgium, koen.cuypers@uhasselt.be
Keywords: Multiple sclerosis; transcranial direct current stimulation; tDCS; neural rehabilitation; motor training
Document URI: http://hdl.handle.net/1942/15913
ISSN: 0922-6028
e-ISSN: 1878-3627
DOI: 10.3233/RNN-130348
ISI #: 000332478200007
Rights: © 2013 – IOS Press and the authors. All rights reserved.
Category: A1
Type: Journal Contribution
Validations: ecoom 2015
Appears in Collections:Research publications

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