Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/15953
Title: The influence of ageing on the development and management of rheumatoid arthritis
Authors: Boots, Annemieke M. H.
Maier, Andrea B.
STINISSEN, Piet 
Masson, Pierre
Lories, Rik J.
De Keyser, Filip
Issue Date: 2013
Source: NATURE REVIEWS RHEUMATOLOGY, 9 (10), p. 604-613
Abstract: The population of elderly individuals with rheumatoid arthritis (RA) is expanding, due mainly to increasing life expectancy. A variety of theories have been proposed to explain the ageing process, including accumulation of DNA damage and resultant changes in biological processes. Such changes can influence the development and/or course of disease. Furthermore, alterations in biological function determine the biological age-as opposed to chronological age-of an individual, which strongly influences their ability to cope with disease. Moreover, comorbidities are more frequent in elderly individuals. Together, these factors complicate treatment of disease and necessitate careful patient management. Indeed, although evidence from clinical trials suggests that DMARDs and biologic agents have good efficacy and are well tolerated in elderly patients with RA, such individuals are often undertreated and inadequately managed. Unfortunately, insufficient data are available for the development of evidence-based guidelines for this population, as elderly patients are often excluded from clinical trials owing to age restrictions or comorbidities. Thus, additional clinical studies in elderly patients are warranted, with treatment regimens tailored according to vitality or frailty parameters. This Review focuses on the pathophysiological aspects of ageing and their implications for the management of RA in elderly patients.
Document URI: http://hdl.handle.net/1942/15953
ISSN: 1759-4790
e-ISSN: 1759-4804
DOI: 10.1038/nrrheum.2013.92
ISI #: 000325145200007
Category: A1
Type: Journal Contribution
Validations: ecoom 2014
Appears in Collections:Research publications

Show full item record

SCOPUSTM   
Citations

33
checked on Sep 2, 2020

WEB OF SCIENCETM
Citations

49
checked on May 21, 2022

Page view(s)

58
checked on May 27, 2022

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.