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Title: | Single-center analysis of biopsy-confirmed posttransplant lymphoproliferative disorder: incidence, clinicopathological characteristics and prognostic factors | Authors: | Dierickx, Daan Tousseyn, Thomas Sagaert, Xavier FIEUWS, Steffen Wlodarska, Iwona Morscio, Julie Brepoels, Lieselot Kuypers, Dirk Vanhaecke, Johan Nevens, Frederik Verleden, Geert Van Damme-Lombaerts, Rita Renard, Marleen Pirenne, Jacques De Wolf-Peeters, Christiane Verhoef, Gregor |
Issue Date: | 2013 | Publisher: | INFORMA HEALTHCARE | Source: | LEUKEMIA & LYMPHOMA, 54 (11), p. 2433-2440 | Abstract: | Hematopoietic stem cell and solid organ transplant recipients diagnosed with biopsy-confirmed posttransplant lymphoproliferative disorder (PTLD) at our institution from 1989 to 2010 were identified. Patient-, transplant- and disease-related characteristics, prognostic factors and outcome were collected and analyzed. One hundred and forty biopsy-proven cases of PTLD were included. Overall incidence in the transplant population was 2.12%, with heart transplant recipients carrying the highest risk. Most PTLDs were monomorphic (82%), with diffuse large B-cell lymphoma being the most frequent subtype. The majority of cases (70.7%) occurred >1 year posttransplant, and 66% were Epstein-Barr virus positive. Following initial therapy the overall response rate was 68.5%. Three-year relapse-free and overall survivals were 59% and 49%, respectively. At last follow-up, 44% of the patients were alive. Multivariable analysis identified several classical lymphoma-specific poor prognostic factors for the different outcome measures. The value of the International Prognostic Index was confirmed in our analysis. | Notes: | [Dierickx, Daan; Verhoef, Gregor] Dept Hematol, Louvain, Belgium. [Tousseyn, Thomas; Sagaert, Xavier; Morscio, Julie; De Wolf-Peeters, Christiane] KU Leuven Translat Cell & Tissue Res, Louvain, Belgium. [Tousseyn, Thomas; Sagaert, Xavier; Morscio, Julie; De Wolf-Peeters, Christiane] UZ Leuven Dept Pathol, Louvain, Belgium. [Brepoels, Lieselot] Katholieke Univ Leuven Hosp, Dept Nucl Med, B-3000 Louvain, Belgium. [Kuypers, Dirk] Katholieke Univ Leuven Hosp, Dept Nephrol & Renal Transplantat, B-3000 Louvain, Belgium. [Vanhaecke, Johan] Katholieke Univ Leuven Hosp, Dept Cardiol, B-3000 Louvain, Belgium. [Nevens, Frederik] Katholieke Univ Leuven Hosp, Dept Hepatol, B-3000 Louvain, Belgium. [Verleden, Geert] Katholieke Univ Leuven Hosp, Dept Pneumol, B-3000 Louvain, Belgium. [Van Damme-Lombaerts, Rita; Renard, Marleen] Katholieke Univ Leuven Hosp, Dept Pediat, B-3000 Louvain, Belgium. [Pirenne, Jacques] Katholieke Univ Leuven Hosp, Dept Abdominal Transplant Surg, B-3000 Louvain, Belgium. [Fieuws, Steffen] Catholic Univ Louvain, Interuniv Inst Biostat & Stat Bioinformat, B-3000 Louvain, Belgium. [Fieuws, Steffen] Univ Hasselt, Diepenbeek, Belgium. [Wlodarska, Iwona] Catholic Univ Louvain, Ctr Human Genet, B-3000 Louvain, Belgium. | Keywords: | Immunosuppression; posttransplant lymphoproliferative disorder; PTLD; transplant;immunosuppression; posttransplant lymphoproliferative disorder; PTLD; transplant | Document URI: | http://hdl.handle.net/1942/15957 | ISSN: | 1042-8194 | e-ISSN: | 1029-2403 | DOI: | 10.3109/10428194.2013.780655 | ISI #: | 000325498900018 | Rights: | © 2013 Informa UK, Ltd. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2014 |
Appears in Collections: | Research publications |
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