Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/15990
Title: Glycine receptors and brain development
Authors: AVILA MACAYA, Ariel 
Nguyen, Laurent
RIGO, Jean-Michel 
Issue Date: 2013
Source: FRONTIERS IN CELLULAR NEUROSCIENCE, 7, (ART N° 184)
Abstract: Glycine receptors (GlyRs) are ligand-gated chloride ion channels that mediate fast inhibitory neurotransmission in the spinal cord and the brainstem. There, they are mainly involved in motor control and pain perception in the adult. However, these receptors are also expressed in upper regions of the central nervous system, where they participate in different processes including synaptic neurotransmission. Moreover, GlyRs are present since early stages of brain development and might influence this process. Here, we discuss the current state of the art regarding GlyRs during embryonic and postnatal brain development in light of recent findings about the cellular and molecular mechanisms that control brain development.
Notes: Rigo, JM (reprint author), Hasselt Univ, Martelarenlaan 42, B-4000 Hasselt, Belgium. jeanmichel.rigo@uhasselt.be
Keywords: glycine receptors; GlyRs; glycine; brain development; cortex; hippocampus; interneurons; migration
Document URI: http://hdl.handle.net/1942/15990
e-ISSN: 1662-5102
DOI: 10.3389/fncel.2013.00184
ISI #: 000326075200002
Category: A1
Type: Journal Contribution
Validations: ecoom 2014
Appears in Collections:Research publications

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