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http://hdl.handle.net/1942/16082
Title: | Progression-Free Survival as a Surrogate for Overall Survival in Advanced/Recurrent Gastric Cancer Trials: A Meta-Analysis | Authors: | PAOLETTI, Xavier Oba, Koji Bang, Yung-Jue Bleiberg, Harry Boku, Narikazu Bouche, Olivier Fuse, Nozomu Michiels, Stefan Moehler, Markus Morita, Satoshi Ohashi, Yasuo Ohtsu, Atsushi Roth, Arnaud Rougier, Philippe Sakamoto, Junichi Sargent, Daniel Sasako, Mitsuru Shitara, Kohei Thuss-Patience, Peter Van Cutsem, Eric BURZYKOWSKI, Tomasz BUYSE, Marc |
Issue Date: | 2013 | Source: | JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 105 (21), p. 1667-1670 | Abstract: | The traditional endpoint for assessing efficacy of chemotherapies for advanced/recurrent gastric cancer is overall survival (OS), but OS requires prolonged follow-up. We investigated whether progression-free survival (PFS) is a valid surrogate for OS. Using individual patient data from the GASTRIC meta-analysis, surrogacy of PFS was assessed through the correlation between the endpoints and through the correlation between the treatment effects on the endpoints. External validation of the prediction based on PFS was also evaluated. Individual data from 4069 patients in 20 randomized trials were analyzed. The rank correlation coefficient between PFS and OS was 0.853 (95% confidence interval [CI] = 0.852 to 0.854). The R-2 between treatment effects on PFS and on OS was 0.61 (95% CI = 0.04 to 1.00). Treatment effects on PFS and on OS were only moderately correlated, and we could not confirm the validity of PFS as a surrogate endpoint for OS in advanced/recurrent gastric cancer. | Document URI: | http://hdl.handle.net/1942/16082 | ISSN: | 0027-8874 | e-ISSN: | 1460-2105 | DOI: | 10.1093/jnci/djt269 | ISI #: | 000326973900013 | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2014 |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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2013_JNCI GASTRIC_Adv_PFS_Surrogate.pdf | 524.11 kB | Adobe PDF | View/Open |
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