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http://hdl.handle.net/1942/16164
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DC Field | Value | Language |
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dc.contributor.author | GARCIA BARRADO, Leandro | - |
dc.contributor.author | COART, Elisabeth | - |
dc.contributor.author | BURZYKOWSKI, Tomasz | - |
dc.date.accessioned | 2014-01-24T13:47:19Z | - |
dc.date.available | 2014-01-24T13:47:19Z | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | Lanzarone, Ettore; Ieva, Francesca (Ed.). The Contribution of Young Researchers to Bayesian Statistics: Proceedings of BAYSM2013, p. 7-10 | - |
dc.identifier.isbn | 978-3-319-02084-6 | - |
dc.identifier.issn | 2194-1009 | - |
dc.identifier.uri | http://hdl.handle.net/1942/16164 | - |
dc.description.abstract | The reference diagnostic test used to establish the discriminative properties of a combination of biomarkers could be imperfect. This may lead to a biased estimate of the accuracy of the combination. A Bayesian latent-class mixture model is proposed to estimate the Area Under the ROC Curve (AUC) of a combination of biomarkers. The model allows selecting the combination that maximizes the AUC and takes possible errors in the reference test into account. A simulation study was performed based on 400 data sets. Sample sizes from 100 to 600 observations were considered. Informative as well as non-informative prior information for the diagnostic accuracy of the reference test was considered. In addition, a controlled prior specification is proposed. The obtained average estimates for all parameters were close to the true values; some differences in efficiency were observed. Results indicate an adequate performance of the model-based estimates. | - |
dc.language.iso | en | - |
dc.publisher | Springer International Publishing | - |
dc.relation.ispartofseries | Springer Proceedings in Mathematics & Statistics | - |
dc.subject.other | Bayesian estimation; latent class mixture models; AUC | - |
dc.title | Estimation of Optimally Combined-Biomarker Accuracy in the Absence of a Gold Standard Reference Test | - |
dc.type | Proceedings Paper | - |
local.bibliographicCitation.authors | Lanzarone, Ettore | - |
local.bibliographicCitation.authors | Ieva, Francesca | - |
local.bibliographicCitation.conferencedate | 5-6 June 2013 | - |
local.bibliographicCitation.conferencename | BAYESIAN YOUNG STATISTICIANS MEETING 2013 | - |
local.bibliographicCitation.conferenceplace | Milan, Italy | - |
dc.identifier.epage | 10 | - |
dc.identifier.spage | 7 | - |
local.bibliographicCitation.jcat | C1 | - |
local.type.refereed | Refereed | - |
local.type.specified | Proceedings Paper | - |
local.relation.ispartofseriesnr | 63 | - |
dc.identifier.doi | 10.1007/978-3-319-02084-6 | - |
local.bibliographicCitation.btitle | The Contribution of Young Researchers to Bayesian Statistics: Proceedings of BAYSM2013 | - |
item.fullcitation | GARCIA BARRADO, Leandro; COART, Elisabeth & BURZYKOWSKI, Tomasz (2013) Estimation of Optimally Combined-Biomarker Accuracy in the Absence of a Gold Standard Reference Test. In: Lanzarone, Ettore; Ieva, Francesca (Ed.). The Contribution of Young Researchers to Bayesian Statistics: Proceedings of BAYSM2013, p. 7-10. | - |
item.fulltext | No Fulltext | - |
item.contributor | GARCIA BARRADO, Leandro | - |
item.contributor | COART, Elisabeth | - |
item.contributor | BURZYKOWSKI, Tomasz | - |
item.accessRights | Closed Access | - |
Appears in Collections: | Research publications |
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