Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/16176
Title: Optimization of the Transcranial Magnetic Stimulation Protocol by Defining a Reliable Estimate for Corticospinal Excitability
Authors: CUYPERS, Koen 
THIJS, Herbert 
MEESEN, Raf 
Issue Date: 2014
Source: PLoS One, 9 (1), (ART N° e86380)
Abstract: The goal of this study was to optimize the transcranial magnetic stimulation (TMS) protocol for acquiring a reliable estimate of corticospinal excitability (CSE) using single-pulse TMS. Moreover, the minimal number of stimuli required to obtain a reliable estimate of CSE was investigated. In addition, the effect of two frequently used stimulation intensities [110% relative to the resting motor threshold (rMT) and 120% rMT] and gender was evaluated. Thirty-six healthy young subjects (18 males and 18 females) participated in a double-blind crossover procedure. They received 2 blocks of 40 consecutive TMS stimuli at either 110% rMT or 120% rMT in a randomized order. Based upon our data, we advise that at least 30 consecutive stimuli are required to obtain the most reliable estimate for CSE. Stimulation intensity and gender had no significant influence on CSE estimation. In addition, our results revealed that for subjects with a higher rMT, fewer consecutive stimuli were required to reach a stable estimate of CSE. The current findings can be used to optimize the design of similar TMS experiments.
Notes: Meesen, RLJ (reprint author), Hasselt Univ, Fac Med & Life Sci, REVAL Rehabil Res Ctr, Biomed Res Inst, Diepenbeek, Belgium, raf.meesen@uhasselt.be
Document URI: http://hdl.handle.net/1942/16176
ISSN: 1932-6203
e-ISSN: 1932-6203
DOI: 10.1371/journal.pone.0086380
ISI #: 000330339800041
Category: A1
Type: Journal Contribution
Validations: ecoom 2015
Appears in Collections:Research publications

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