Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/1618
Title: Leukemia inhibitory factor is produced by myelin-reactive T cells from multiple sclerosis patients and protects against tumor necrosis factor-α-induced oligodendrocyte apoptosis
Authors: VANDERLOCHT, Joris 
HELLINGS, Niels 
HENDRIKS, Jerome 
VANDENABEELE, Frank 
MOREELS, Marjan 
BUNTINX, Mieke 
Hoekstra, D.
Antel, J.
STINISSEN, Piet 
Issue Date: 2006
Publisher: Wiley
Source: JOURNAL OF NEUROSCIENCE RESEARCH, 83(5). p. 763-774
Abstract: In multiple sclerosis (MS), damage to oligodendrocytes is believed to be caused by an aberrant immune response initiated by autoreactive Tcells. Increasing evidence indicates that these Tcells are not exclusively detrimental but might also exert protective effects. We report for the first time that myelin-reactive T-cell clones from eight MS patients (6/19) and five healthy controls (4/11) produce leukemia inhibitory factor (LIF), a member of the neuropoietic family of neurotrophins. In addition, T-cell clones specific for tetanus toxoid, CD4[+] and CD8[+] T cells, and monocytes, but not B cells, secreted LIF. LIF-producing T lymphocytes and macrophages were also identified immunohistochemically in both active and chronic-active MS lesions. We further demonstrated dose-dependent protective effects of LIF on tumor necrosis factor-α-induced apoptosis of oligodendrocytes. In conclusion, our data demonstrate that peripheral and CNS-infiltrating T cells from MS patients produce LIF, a protective factor for oligodendrocytes. This study emphasizes that secretion of LIF may contribute to the neuroprotective effects of autoreactive T cells.
Keywords: multiple sclerosis ; oligodendrocytes ; leukemia inhibitory factor ; myelin-reactive T cells ;
Document URI: http://hdl.handle.net/1942/1618
ISSN: 0360-4012
e-ISSN: 1097-4547
DOI: 10.1002/jnr.20781
ISI #: 000236636300005
Category: A1
Type: Journal Contribution
Validations: ecoom 2007
Appears in Collections:Research publications

Files in This Item:
File Description SizeFormat 
Leukemia I.pdfPostprint350.65 kBAdobe PDFView/Open
20781_ftp.pdf
  Restricted Access
Published version400.61 kBAdobe PDFView/Open    Request a copy
Show full item record

SCOPUSTM   
Citations

51
checked on Sep 3, 2020

WEB OF SCIENCETM
Citations

49
checked on May 22, 2022

Page view(s)

48
checked on May 26, 2022

Download(s)

228
checked on May 26, 2022

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.