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http://hdl.handle.net/1942/16333
Title: | Semen quality and prediction of IUI success in male subfertility: a systematic review | Authors: | OMBELET, Willem DHONT, Nathalie THIJSSEN, Annelies BOSMANS, Eugene KRUGER, Thinus |
Issue Date: | 2014 | Source: | REPRODUCTIVE BIOMEDICINE ONLINE, 28, p. 300-309 | Abstract: | Many variables may influence success rates after intrauterine insemination (IUI), including sperm quality in the native and washed semen sample. A literature search was performed to investigate the threshold levels of sperm parameters above which IUI pregnancy outcome is significantly improved and/or the cut-off values reaching substantial discriminative performance in an IUI programme. A search of MEDLINE, EMBASE and Cochrane Library revealed a total of 983 papers. Only 55 studies (5.6%) fulfilled the inclusion criteria and these papers were analysed. Sperm parameters most frequently examined were: (i) inseminating motile count after washing: cut-off value between 0.8 and 5 million; (ii) sperm morphology using strict criteria: cut-off value 5% normal morphology; (iii) total motile sperm count in the native sperm sample: cut-off value of 5–10 million; and (iv) total motility in the native sperm sample: threshold value of 30%. The results indicate a lack of prospective studies, a lack of standardization in semen testing methodology and a huge heterogeneity of patient groups and IUI treatment strategies. More prospective cohort trials and prospective randomized trials investigating the predictive value of semen parameters on IUI outcome are urgently needed. | Notes: | [Ombelet, Willem; Dhont, Nathalie; Thijssen, Annelies; Bosmans, Eugene] Genk Inst Fertil Technol, Dept Obstet & Gynaecol, Genk, Belgium. [Ombelet, Willem; Thijssen, Annelies] Hasselt Univ, Fac Med & Life Sci, Hasselt, Belgium. [Kruger, Thinus] Univ Stellenbosch, Dept Obstet & Gynaecol, Reprod Biol Unit, ZA-7505 Tygerberg, South Africa. [Kruger, Thinus] Tygerberg Hosp, Tygerberg, South Africa. | Keywords: | assisted reproduction; intrauterine insemination; predictive value; pregnancy rate; semen; sperm quality | Document URI: | http://hdl.handle.net/1942/16333 | ISSN: | 1472-6483 | e-ISSN: | 1472-6491 | DOI: | 10.1016/j.rbmo.2013.10.023 | ISI #: | 000332413900007 | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2015 |
Appears in Collections: | Research publications |
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