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http://hdl.handle.net/1942/1633
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DC Field | Value | Language |
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dc.contributor.author | HELLINGS, Niels | - |
dc.contributor.author | RAUS, Jef | - |
dc.contributor.author | STINISSEN, Piet | - |
dc.date.accessioned | 2007-06-15T09:21:02Z | - |
dc.date.available | 2007-06-15T09:21:02Z | - |
dc.date.issued | 2006 | - |
dc.identifier.citation | Expert Review of Clinical Immunology, 2(5). p. 705-716 | - |
dc.identifier.issn | 1744-666X | - |
dc.identifier.uri | http://hdl.handle.net/1942/1633 | - |
dc.description.abstract | Multiple sclerosis (MS) is a chronic inflammatory disease of the CNS with presumed autoimmune origin. Pathogenic autoimmune responses in MS are thought to be the result of a breakdown of self tolerance. Several mechanisms account for the natural state of immunological tolerance to self antigens, including clonal deletion of self-reactive T cells in the thymus. However, autoimmune T cells are also part of the normal T-cell repertoire, supporting the existence of peripheral regulatory mechanisms that keep these potentially pathogenic T cells under control. One such mechanism involves active suppression by regulatory T cells. It has been indicated that regulatory T cells do not function properly in autoimmune disease. Immunization with attenuated autoreactive T cells, T-cell vaccination, may enhance or restore the regulatory immune networks to specifically suppress autoreactive T cells, as shown in experimental autoimmune encephalomyelitis, an animal model for MS. In the past decade, T-cell vaccination has been tested for MS in several clinical trials. This review summarizes these clinical trials and updates our current knowledge on the induction of regulatory immune networks by T cell vaccination. | - |
dc.language.iso | en | - |
dc.publisher | Future drugs | - |
dc.subject.other | anticlonotypic T cells; antiergotypic T cells; autoreactive T cells; Qa-1-dependent T cells; regulatory networks; T-cell vaccination | - |
dc.title | T-cell-based immunotherapy in multiple sclerosis: induction of regulatory immune networks by T-cell vaccination | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 716 | - |
dc.identifier.issue | 5 | - |
dc.identifier.spage | 705 | - |
dc.identifier.volume | 2 | - |
local.bibliographicCitation.jcat | A2 | - |
local.type.refereed | Refereed | - |
dc.bibliographicCitation.oldjcat | A2 | - |
dc.identifier.doi | 10.1586/1744666X.2.5.705 | - |
item.fullcitation | HELLINGS, Niels; RAUS, Jef & STINISSEN, Piet (2006) T-cell-based immunotherapy in multiple sclerosis: induction of regulatory immune networks by T-cell vaccination. In: Expert Review of Clinical Immunology, 2(5). p. 705-716. | - |
item.fulltext | No Fulltext | - |
item.contributor | HELLINGS, Niels | - |
item.contributor | RAUS, Jef | - |
item.contributor | STINISSEN, Piet | - |
item.accessRights | Closed Access | - |
crisitem.journal.issn | 1744-666X | - |
crisitem.journal.eissn | 1744-8409 | - |
Appears in Collections: | Research publications |
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