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http://hdl.handle.net/1942/16342
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DC Field | Value | Language |
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dc.contributor.author | FRAUSSEN, Judith | - |
dc.contributor.author | Vrolix, Kathleen | - |
dc.contributor.author | CLAES, Nele | - |
dc.contributor.author | Martinez-Martinez, Pilar | - |
dc.contributor.author | Losen, Mario | - |
dc.contributor.author | Hupperts, Raymond | - |
dc.contributor.author | VAN WIJMEERSCH, Bart | - |
dc.contributor.author | Espiño, Mercedes | - |
dc.contributor.author | Villar, Luisa M. | - |
dc.contributor.author | DE BAETS, Marc | - |
dc.contributor.author | STINISSEN, Piet | - |
dc.contributor.author | SOMERS, Veerle | - |
dc.date.accessioned | 2014-02-17T09:55:13Z | - |
dc.date.available | 2014-02-17T09:55:13Z | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | JOURNAL OF NEUROIMMUNOLOGY, 261 (1-2), p. 98-107 | - |
dc.identifier.issn | 0165-5728 | - |
dc.identifier.uri | http://hdl.handle.net/1942/16342 | - |
dc.description.abstract | We studied Ig heavy chain (VDJ) sequences and antigen reactivity of 412 immortalized B cell lines from the peripheral blood of 10 multiple sclerosis (MS) patients, 4 clinically isolated syndrome (CIS) patients and 6 healthy controls (HCs). 78/238 (32.8%) MS and CIS B cell lines were part of 9 clonally expanded B cell populations, of which 5 were present in multiple patients. Increased VH1 gene family usage was evidenced for MS B cells, with 29.2% expressing VH1-69. Affinity maturation in MS and CIS was indicated by increased Ig VDJ mutations. Autoantibody producing B cells reactive to intracellular antigens were significantly higher in MS (25%) and CIS (28%) patients than in HCs (5%), including 3/9 expanded B cell clones. Specificity for phosphatidylcholine was observed for 1/9 B cell clones. These findings indicate clonally expanded autoreactive B cells with affinity maturation in the peripheral blood in MS and CIS | - |
dc.language.iso | en | - |
dc.rights | © 2013 Elsevier B.V. All rights reserved. | - |
dc.subject.other | Autoreactivity; B cell immortalization; Clinically isolated syndrome; Clonal B cell expansion; Complementarity determining region 3; Multiple sclerosis | - |
dc.title | Autoantigen induced clonal expansion in immortalized B cells from the peripheral blood of multiple sclerosis patients | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 107 | - |
dc.identifier.issue | 1-2 | - |
dc.identifier.spage | 98 | - |
dc.identifier.volume | 261 | - |
local.bibliographicCitation.jcat | A1 | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1016/j.jneuroim.2013.05.002 | - |
dc.identifier.isi | 000323459400014 | - |
item.fullcitation | FRAUSSEN, Judith; Vrolix, Kathleen; CLAES, Nele; Martinez-Martinez, Pilar; Losen, Mario; Hupperts, Raymond; VAN WIJMEERSCH, Bart; Espiño, Mercedes; Villar, Luisa M.; DE BAETS, Marc; STINISSEN, Piet & SOMERS, Veerle (2013) Autoantigen induced clonal expansion in immortalized B cells from the peripheral blood of multiple sclerosis patients. In: JOURNAL OF NEUROIMMUNOLOGY, 261 (1-2), p. 98-107. | - |
item.contributor | FRAUSSEN, Judith | - |
item.contributor | Vrolix, Kathleen | - |
item.contributor | CLAES, Nele | - |
item.contributor | Martinez-Martinez, Pilar | - |
item.contributor | Losen, Mario | - |
item.contributor | Hupperts, Raymond | - |
item.contributor | VAN WIJMEERSCH, Bart | - |
item.contributor | Espiño, Mercedes | - |
item.contributor | Villar, Luisa M. | - |
item.contributor | DE BAETS, Marc | - |
item.contributor | STINISSEN, Piet | - |
item.contributor | SOMERS, Veerle | - |
item.validation | ecoom 2014 | - |
item.accessRights | Restricted Access | - |
item.fulltext | With Fulltext | - |
crisitem.journal.issn | 0165-5728 | - |
crisitem.journal.eissn | 1872-8421 | - |
Appears in Collections: | Research publications |
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1-s2.0-S0165572813001343-main.pdf Restricted Access | Published version | 860.96 kB | Adobe PDF | View/Open Request a copy |
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