Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/1641
Title: Current trends in multiple sclerosis research: an update on pathogenic concepts
Authors: VANDERLOCHT, Joris 
HELLINGS, Niels 
HENDRIKS, Jerome 
STINISSEN, Piet 
Issue Date: 2006
Publisher: Royal Association of Belgian Medical Scientific Societies
Source: ACTA NEUROLOGICA BELGICA, 106(4). p. 180-190
Abstract: Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) of presumed autoimmune origin which develops in a genetic susceptible individual triggered by additional environmental factors. In this review we will provide an update of basic pathogenic concepts. In addition, we will discuss newly evolving concepts in MS pathogenesis such as pathogenic heterogeneity, importance of axonal loss and the role of CD8+ T lymphocytes in tissue injury. In the last part of this review we will briefly describe currently approved MS treatments and summarize some promising therapeutic approaches that are currently under evaluation.
Notes: Hasselt Univ, Biomed Onderzoeksinst, B-3590 Diepenbeek, Belgium. Transnatl Univ Limburg, Sch Life Sci, Diepenbeek, Belgium.
Keywords: clinical neurology; neurosciences;CENTRAL-NERVOUS-SYSTEM; DISEASE; MULTIPLE-SCLEROSIS;
Document URI: http://hdl.handle.net/1942/1641
Link to publication: http://www.actaneurologica.be/acta/article.asp?lang=en&navid=137&id=14157&mod=acta
ISSN: 0300-9009
e-ISSN: 2240-2993
ISI #: 000244297800005
Category: A1
Type: Journal Contribution
Validations: ecoom 2008
Appears in Collections:Research publications

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