Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/16472
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dc.contributor.authorHANSEN, Dominique-
dc.contributor.authorWENS, Inez-
dc.contributor.authorDENDALE, Paul-
dc.contributor.authorOP 'T EIJNDE, Bert-
dc.date.accessioned2014-03-24T12:52:52Z-
dc.date.available2014-03-24T12:52:52Z-
dc.date.issued2013-
dc.identifier.citationNEUROREHABILITATION, 33 (1), p. 139-146-
dc.identifier.issn1053-8135-
dc.identifier.urihttp://hdl.handle.net/1942/16472-
dc.description.abstractOBJECTIVE:To explore the etiology of exercise intolerance in patients with MS, it is analyzed whether a disturbed cardiac autonomic control could be observed during exercise testing in patients with MS, and is related to exercise tolerance. PATIENTS AND METHOD:From 26 MS patients and 15 healthy subjects, exercise-onset (first 20 and 60 seconds) and –offset (1-minute recovery) HR change was determined during a 6-minute constant-load exercise bout on bike. Blood lactate, HR, oxygen uptake, expiratory volume and perceived exertion were assessed during exercise, and compared between groups. In 15 MS patients, a 6-min walking test was executed. RESULT:Twenty-second exercise-onset HR increase was significantly smaller in MS patients (14±7 bts/min) vs. healthy subjects (20±8 bts/min,p< 0.05), and independently related to MS and age in total group (p< 0.05). Sixty-second exercise-onset and –offset HR changes were not different between groups, nor independently related to MS presence (p> 0.05). A significant correlation was found between 20-second exercise-onset HR increase and walking capacity in MS patients (r= 0.64,p< 0.01). CONCLUSION:In MS patients, the early increase in heart rate during endurance exercise is significantly slowed, indicating a disturbed cardiac autonomic control, and is related to exercise tolerance.-
dc.language.isoen-
dc.rights© 2013 – IOS Press and the authors. All rights reserved.-
dc.subject.othermultiple sclerosis; endurance exercise; exercise testing; heart rate; autonomic control-
dc.titleExercise-onset heart rate increase is slowed in multiple sclerosis patients: does a disturbed cardiac autonomic control affect exercise tolerance?-
dc.typeJournal Contribution-
dc.identifier.epage146-
dc.identifier.issue1-
dc.identifier.spage139-
dc.identifier.volume33-
local.bibliographicCitation.jcatA1-
local.type.refereedRefereed-
local.type.specifiedArticle-
dc.identifier.doi10.3233/NRE-130938-
dc.identifier.isi000324260400018-
item.fulltextWith Fulltext-
item.accessRightsRestricted Access-
item.contributorHANSEN, Dominique-
item.contributorWENS, Inez-
item.contributorDENDALE, Paul-
item.contributorOP 'T EIJNDE, Bert-
item.fullcitationHANSEN, Dominique; WENS, Inez; DENDALE, Paul & OP 'T EIJNDE, Bert (2013) Exercise-onset heart rate increase is slowed in multiple sclerosis patients: does a disturbed cardiac autonomic control affect exercise tolerance?. In: NEUROREHABILITATION, 33 (1), p. 139-146.-
item.validationecoom 2014-
crisitem.journal.issn1053-8135-
crisitem.journal.eissn1878-6448-
Appears in Collections:Research publications
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