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http://hdl.handle.net/1942/16501
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DC Field | Value | Language |
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dc.contributor.author | ZAMANZAD GHAVIDEL, Fatemeh | - |
dc.contributor.author | CLAESEN, Jurgen | - |
dc.contributor.author | BURZYKOWSKI, Tomasz | - |
dc.contributor.author | VALKENBORG, Dirk | - |
dc.date.accessioned | 2014-03-26T08:40:46Z | - |
dc.date.available | 2014-03-26T08:40:46Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 25 (2), p. 293-296 | - |
dc.identifier.issn | 1044-0305 | - |
dc.identifier.uri | http://hdl.handle.net/1942/16501 | - |
dc.description.abstract | To extract a genuine peptide signal from a mass spectrum, an observed series of peaks at a particular mass can be compared with the isotope distribution expected for a peptide of that mass. To decide whether the observed series of peaks is similar to the isotope distribution, a similarity measure is needed. In this short communication, we investigate whether the Mahalanobis distance could be an alternative measure for the commonly employed Pearson’s χ2 statistic. We evaluate the performance of the two measures by using a controlled MALDI-TOF experiment. The results indicate that Pearson’s χ2 statistic has better discriminatory performance than the Mahalanobis distance and is a more robust measure. | - |
dc.description.sponsorship | SBO grant 'InSPECtor' of the Flemish agency for Innovation by Science and Technology (IWT) (grant number 120025) | - |
dc.language.iso | en | - |
dc.rights | © American Society for Mass Spectrometry, 2013. | - |
dc.subject.other | similarity statistics; isotope distributions; mass spectral data interpretation; bioinformatics; mahalanobis distance | - |
dc.title | Comparison of the Mahalanobis Distance and Pearson's χ(2) Statistic as Measures of Similarity of Isotope Patterns. | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 296 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 293 | - |
dc.identifier.volume | 25 | - |
local.bibliographicCitation.jcat | A1 | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1007/s13361-013-0773-z | - |
dc.identifier.isi | 000330828700015 | - |
item.contributor | ZAMANZAD GHAVIDEL, Fatemeh | - |
item.contributor | CLAESEN, Jurgen | - |
item.contributor | BURZYKOWSKI, Tomasz | - |
item.contributor | VALKENBORG, Dirk | - |
item.validation | ecoom 2015 | - |
item.fullcitation | ZAMANZAD GHAVIDEL, Fatemeh; CLAESEN, Jurgen; BURZYKOWSKI, Tomasz & VALKENBORG, Dirk (2014) Comparison of the Mahalanobis Distance and Pearson's χ(2) Statistic as Measures of Similarity of Isotope Patterns.. In: JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 25 (2), p. 293-296. | - |
item.accessRights | Restricted Access | - |
item.fulltext | With Fulltext | - |
crisitem.journal.issn | 1044-0305 | - |
crisitem.journal.eissn | 1879-1123 | - |
Appears in Collections: | Research publications |
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art%3A10.1007%2Fs13361-013-0773-z.pdf Restricted Access | 267.02 kB | Adobe PDF | View/Open Request a copy |
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