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http://hdl.handle.net/1942/16541
Title: | 7,8-Dihydroxyflavone improves memory consolidation processes in rats and mice. | Authors: | BOLLEN, Eva VANMIERLO, Tim Akkerman, Sven Wouters, C. STEINBUSCH, Harry Prickaerts, Jos |
Issue Date: | 2013 | Source: | BEHAVIOURAL BRAIN RESEARCH, 257, p. 8-12 | Abstract: | Brain-derived neurotrophic factor (BDNF) is a crucial regulator of neuronal survival and neuroplasticity in the central nervous system (CNS). As a result, there has been a growing interest in the role of BDNF in neuropsychiatric disorders associated with neurodegeneration, including depression and dementia. However, until now, BDNF-targeting therapies have yielded disappointing results. BDNF is thought to exert its beneficial effects on synaptic and neuronal plasticity mainly through binding to the tyrosine kinase B (TrkB) receptor. Recently, 7,8-dihydroxyflavone (7,8-DHF) was identified as the first selective TrkB agonist. In the present study the effect of 7,8-DHF on memory consolidation processes was evaluated. In healthy rats, 7,8-DHF improved object memory formation in the object recognition task when administered both immediately and 3h after learning. In a transgenic mouse model of Alzheimer's disease, i.e. APPswe/PS1dE9 mice, spatial memory as measured in the object location task was improved after administration of 7,8-DHF. A similar memory improvement was found when their wild-type littermates were treated with 7,8-DHF. The acute beneficial effects in healthy mice suggest that effects might be symptomatic rather than curing. Nevertheless, this study suggests that 7,8-DHF might be a promising therapeutic target for dementia. | Keywords: | 7;8-DHF; 7;8-Dihydroxyflavone; 7;8-dihydroxyflavone; AD; Alzheimer's disease; Aβ; BDNF; brain-derived neurotrophic factor; CNS; CREB; Ca(2+)/calmodulin-dependent protein kinase II; CaMKII; cognition enhancers; LTP; memory consolidation; N-methyl-d-aspartic acid; NMDA; OLT; ORT; PTSD; T1; T2; TrkB; TrkB receptor; WT; amyloid beta; brain-derived neurotrophic factor; cAMP-responsive element binding; central nervous system; first trial; i.p.; intraperitoneal; long-term potentiation; mBDNF; mature BDNF; object location task; object recognition task; p.o.; per os; post-traumatic stress disorder; precursor of BDNF; proBDNF; second trial; tyrosine kinase B; wild-type | Document URI: | http://hdl.handle.net/1942/16541 | ISSN: | 0166-4328 | e-ISSN: | 1872-7549 | DOI: | 10.1016/j.bbr.2013.09.029 | ISI #: | 000328519200002 | Rights: | Copyright © 2013 Elsevier B.V. All rights reserved. | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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