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http://hdl.handle.net/1942/16680
Title: | First births with a simplified culture system for clinical IVF and embryo transfer | Authors: | Van Blerkom, Jonathan OMBELET, Willem Klerkx, Elke Janssen, Mia Dhont, Nathalie NARGUND, Geeta Campo, Rudi |
Issue Date: | 2014 | Source: | REPRODUCTIVE BIOMEDICINE ONLINE, 28 (3), p. 310-320 | Abstract: | This study reports the outcome results froma pilot clinical trial using a simplified laboratorymethod for human IVF. This system reproducibly generates de novo the atmospheric and culture conditions that support normal fertilization and preimplantationembryogenesis to the hatched blastocyst stage without the need for specializedmedical-grade gases or equipment. Development from insemination to the hatched blastocyst stage occurs undisturbed in a completely closed systemthat enables timed performance assessments forembryo selection in situ that, in this study, involvedsingle-embryo transfers onday 3.With the simplified culture system, 8/23embryos implanted, onemiscarried at 8 weeks of gestation and seven healthy babies have been born. Themethodology and results are discussed with regard to how this simplified system can be adopted worldwide to meet the growing need for accessible and affordable IVF. | Keywords: | accessible IVF; infertility; low-cost IVF; simplified IVF; IVF in developing countires; IVF in developed word | Document URI: | http://hdl.handle.net/1942/16680 | ISSN: | 1472-6483 | e-ISSN: | 1472-6491 | DOI: | 10.1016/j.rbmo.2013.11.012 | ISI #: | 000332413900008 | Rights: | © 2013, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2015 |
Appears in Collections: | Research publications |
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van blerkom 1.pdf Restricted Access | Published version | 1.45 MB | Adobe PDF | View/Open Request a copy |
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